Lactoferrin as a Natural Immune Modulator

被引：320
作者：
Actor, Jeffrey K. [1 ]
Hwang, Shen-An
Kruzel, Marian L. [2 ]
机构：
[1] Univ Texas Hlth Sci Ctr Houston, Dept Pathol & Lab Med, UT Houston Med Sch, Houston, TX 77030 USA
[2] Univ Texas Hlth Sci Ctr Houston, Dept Integrat Biol & Pharmacol, Houston, TX 77030 USA
来源：
CURRENT PHARMACEUTICAL DESIGN | 2009年 / 15卷 / 17期
关键词：
Lactoferrin; innate immunity; adaptive immunity; immunomodulation; inflammation; oxidative stress; adjuvant; LANGERHANS CELL-MIGRATION; VIRULENT MYCOBACTERIUM-TUBERCULOSIS; ORALLY-ADMINISTERED LACTOFERRIN; DELAYED-TYPE HYPERSENSITIVITY; INTERFERON-GAMMA PRODUCTION; BLOOD MONONUCLEAR-CELLS; VIRUS TYPE-1 INFECTION; MONOPHOSPHORYL-LIPID-A; BOVINE LACTOFERRIN; OXIDATIVE STRESS;
D O I：
10.2174/138161209788453202
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Lactoferrin, an iron-binding glycoprotein, is a cell-secreted mediator that bridges innate and adaptive immune function in mammals. It is a pleiotropic molecule that directly assists in the influence of presenting cells for the development of T-helper cell polarization. The aim of this review is to provide an overview of research regarding the role of lactoferrin in maintaining immune homeostasis, in particular as a mediator of immune responses to infectious assault, trauma and injury. These findings are critically relevant in the development of both prophylactic and therapeutic interventions in humans. Understanding these particular effects of lactoferrin will provide a logical framework for determining its role in health and disease.
引用
收藏
页码：1956 / 1973
页数：18
相关论文
共 205 条
[1]   Lactoferrin immunomodulation of DTH response in mice [J].
Actor, JK ;
Hwang, SA ;
Olsen, M ;
Zimecki, M ;
Hunter, RL ;
Kruzel, ML .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2002, 2 (04) :475-486
[2]  
Adamik Barbara, 1997, Archivum Immunologiae et Therapiae Experimentalis, V45, P169
[3]  
Adamik Barbara, 1997, Archivum Immunologiae et Therapiae Experimentalis, V45, P277
[4]   Functional plasticity of an antigen-specific memory CD4 T cell population [J].
Ahmadzadeh, M ;
Farber, DL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (18) :11802-11807
[5]   Immune abnormalities and endotoxemia in patients with ulcerative colitis and in their first degree relatives: Attempts at neutralizing endotoxin-mediated effects [J].
Amati, L ;
Caradonna, L ;
Leandro, G ;
Magrone, T ;
Minenna, M ;
Faleo, G ;
Pellegrino, NM ;
Jirillo, E ;
Caccavo, D .
CURRENT PHARMACEUTICAL DESIGN, 2003, 9 (24) :1937-1945
[6]   Bovine lactoferrin prevents the entry and intercellular spread of herpes simplex virus type 1 in Green Monkey Kidney cells [J].
Ammendolia, Maria Grazia ;
Marchetti, Magda ;
Superti, Fabiana .
ANTIVIRAL RESEARCH, 2007, 76 (03) :252-262
[7]   Lactoferrin accelerates reconstitution of the humoral and cellular immune response during chemotherapy-induced immunosuppression and bone marrow transplant in mice [J].
Artym, J ;
Zimecki, M ;
Kuryszko, J ;
Kruzel, ML .
STEM CELLS AND DEVELOPMENT, 2005, 14 (05) :548-555
[8]  
Artym J, 2004, ANTICANCER RES, V24, P3831
[9]   Reconstitution of the cellular immune response by lactoferrin in cyclophosphamide-treated mice is correlated with renewal of T cell compartment [J].
Artym, J ;
Zimecki, M ;
Kruzel, ML .
IMMUNOBIOLOGY, 2003, 207 (03) :197-205
[10]   Orally administered lactoferrin restores humoral immune response in immunocompromised mice [J].
Artyrn, J ;
Zimecki, M ;
Paprocka, M ;
Kruzel, ML .
IMMUNOLOGY LETTERS, 2003, 89 (01) :9-15
12345678910