IL-6 blockers in systemic onset juvenile idiopathic arthritis

被引：15

作者：

Barone, Patrizia ^{[1
]}

Pignataro, Rossana ^{[1
]}

Garozzo, Maria Teresa ^{[1
]}

Leonardi, Salvatore ^{[1
]}

机构：

[1] Univ Catania, Dept Clin & Expt Med, I-95124 Catania, Italy

来源：

IMMUNOTHERAPY | 2016年 / 8卷 / 01期

关键词：

interleukin; 6; systemic onset idiopathic arthritis; tocilizumab; INTERLEUKIN (IL)-6; SIGNAL TRANSDUCER; DOUBLE-BLIND; PHASE-II; GENE; EFFICACY; SAFETY; TOCILIZUMAB; ASSOCIATION; EXPRESSION;

D O I：

10.2217/imt.15.104

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-6 has a key role in the pathogenesis, clinical manifestations and activity of Systemic Onset Idiopathic Arthritis (sJIA). Tocilizumab (TCZ), the first humanized antihuman IL-6 receptor antibody, inhibits the activity of IL-6. In this review, we summarize the main studies performed, to date, about the use of TCZ in children affected by sJIA refractory to conventional treatment. Nowadays TCZ can be used, alone or in association with Metotrexate, in children older than 2 years. Its use in children younger than 2 years is being investigated. Further study about its use in sJIA and other type of idiopathic arthritis should be done.

引用

页码：79 / 87

页数：9

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