Resveratrol enhances the suppressive effects of arsenic trioxide on primitive leukemic progenitors

被引：14

作者：

Wu, Edward J. ^{[1
]}

Goussetis, Dennis J. ^{[1
,2
,3
]}

Beauchamp, Elspeth ^{[1
,2
]}

Kosciuczuk, Ewa M. ^{[1
]}

Altman, Jessica K. ^{[1
,2
,3
]}

Eklund, Elizabeth A. ^{[1
,2
,3
]}

Platanias, Leonidas C. ^{[1
,2
,3
]}

机构：

[1] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

[2] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Hematol Oncol, Chicago, IL 60611 USA

[3] Jesse Brown VA Med Ctr, Dept Med, Chicago, IL USA

来源：

CANCER BIOLOGY & THERAPY | 2014年 / 15卷 / 04期

基金：

美国国家卫生研究院;

关键词：

arsenic trioxide; myeloid leukemia; apoptosis; autophagy; ACTIVATED PROTEIN-KINASE; ABL-EXPRESSING CELLS; ANTILEUKEMIC RESPONSES; CELLULAR-RESPONSES; INDUCED APOPTOSIS; MAMMALIAN TARGET; I INTERFERONS; GENERATION; CANCER; RAPAMYCIN;

D O I：

10.4161/cbt.27824

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Efforts to enhance the antileukemic properties of arsenic trioxide are clinically relevant and may lead to the development of new therapeutic approaches for the management of certain hematological malignancies. We provide evidence that concomitant treatment of acute myeloid leukemia (AML) cells or chronic myeloid leukemia (CML) cells with resveratrol potentiates arsenic trioxide-dependent induction of apoptosis. Importantly, clonogenic assays in methylcellulose demonstrate potent suppressive effects of the combination of these agents on primitive leukemic progenitors derived from patients with AML or CML. Taken together, these findings suggest that combinations of arsenic trioxide with resveratrol may provide an approach for targeting of early leukemic precursors and, possibly, leukemia initiating stem cells.

引用

页码：473 / 478

页数：6

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