Variation in tryptophan hydroxylase-2 gene is not associated to male completed suicide in Estonian population

被引：16

作者：

Must, Anne ^{[1
]}

Tasa, Gunnar ^{[2
]}

Lang, Aavo ^{[1
]}

Vasar, Eero ^{[1
]}

Koks, Sulev ^{[1
,3
]}

Maron, Eduard ^{[4
]}

Vaeli, Marika ^{[5
]}

机构：

[1] Univ Tartu, Inst Physiol, EE-50411 Tartu, Estonia

[2] Univ Tartu, Inst Gen & Mol Pathol, EE-50411 Tartu, Estonia

[3] Estonian Univ Life Sci, Inst Vet Med & Anim Sci, EE-51014 Tartu, Estonia

[4] Tartu Univ Hosp, Psychiat Clin, EE-50417 Tartu, Estonia

[5] Univ Tartu, Inst Pathol Anat & Forens Med, EE-50411 Tartu, Estonia

来源：

NEUROSCIENCE LETTERS | 2009年 / 453卷 / 02期

关键词：

Tryptophan hydroxylase; TPH2; Suicide; SNP; Serotonin; DORSAL RAPHE NUCLEUS; OF-FUNCTION MUTATION; ISOFORM TPH2 GENE; MAJOR DEPRESSION; HAPLOTYPE ANALYSIS; PROMOTER POLYMORPHISM; BIPOLAR DISORDER; TRYPTOPHAN-HYDROXYLASE-2; SNP; SEROTONIN;

D O I：

10.1016/j.neulet.2009.02.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dysfunction of the central serotonergic system has been related to a spectrum of psychiatric disorders, including suicidal behavior. Tryptophan hydroxylase isoform 2 (TPH2) is the rate-limiting enzyme in the biosynthetic pathway of serotonin, being expressed in serotonergic neurons of raphe nuclei. We investigated genetic variation in TPH2 gene in two samples of male subjects: 288 suicide completers and 327 volunteers, in order to reveal any associations between 14 single nucleotide polymorphisms and completed suicide. No associations were revealed neither on allelic nor haplotype level. Our finding does not support the hypothesis of TPH2 being a susceptibility factor for completed suicide in males of Estonian origin. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：112 / 114

页数：3

共 21 条

[1]

ASBERG M, 1976, ARCH GEN PSYCHIAT, V33, P1193

[2] Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: Major depression and suicide [J].