Regulatory T Cells: the Many Faces of Foxp3

被引：203

作者：

Georgiev, Peter ^{[1
,2
,3
]}

Charbonnier, Louis-Marie ^{[1
,2
]}

Chatila, Talal A. ^{[1
,2
]}

机构：

[1] Harvard Med Sch, Div Immunol, Boston Childrens Hosp, Boston, MA 02115 USA

[2] Harvard Med Sch, Dept Pediat, Boston, MA 02115 USA

[3] Merck & Co Inc, Kenilworth, NJ USA

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2019年 / 39卷 / 07期

基金：

美国国家卫生研究院;

关键词：

Autoimmunity; Foxp3; immune dysregulation; immune tolerance; immunometabolism; interleukin; 2; IPEX; rapamycin; regulatory T cells; regulatory T cell reprogramming; LOW-DOSE INTERLEUKIN-2; TRANSCRIPTION FACTOR FOXP3; X-LINKED IPEX; IMMUNE DYSREGULATION; DENDRITIC CELLS; IL-2; RECEPTOR; CUTTING EDGE; REG CELLS; MEDIATED INDUCTION; DEFICIENCY CAUSES;

D O I：

10.1007/s10875-019-00684-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a requisite role in the maintenance of immunological homeostasis and prevention of peripheral self-tolerance breakdown. Although Foxp3 by itself is neither necessary nor sufficient to specify many aspects of the Treg cell phenotype, its sustained expression in Treg cells is indispensable for their phenotypic stability, metabolic fitness, and regulatory function. In this review, we summarize recent advances in Treg cell biology, with a particular emphasis on the role of Foxp3 as a transcriptional modulator and metabolic gatekeeper essential to an effective immune regulatory response. We discuss these findings in the context of human inborn errors of immune dysregulation, with a focus on FOXP3 mutations, leading to Treg cell deficiency. We also highlight emerging concepts of therapeutic Treg cell reprogramming to restore tolerance in the settings of immune dysregulatory disorders.

引用

页码：623 / 640

页数：18

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