The effects of exercise on kidney injury: the role of SIRT1

被引:10
作者
Sabet, Nazanin [1 ,2 ,4 ]
Soltani, Zahra [1 ,2 ,4 ]
Khaksari, Mohammad [2 ,3 ]
机构
[1] Kerman Univ Med Sci, Res Ctr Trop & Infect Dis, Kerman, Iran
[2] Kerman Univ Med Sci, Fac Med, Endocrinol & Metab Res Ctr, Inst Basic & Clin Physiol Sci, Kerman, Iran
[3] Kerman Univ Med Sci, Physiol Res Ctr, Inst Neuropharmacol, Kerman, Iran
[4] Kerman Univ Med Sci, Afzalipour Fac Med, Dept Physiol & Pharmacol, Kerman, Iran
关键词
Kidney injury; Physical activity; SIRT1; Inflammation; SKELETAL-MUSCLE; AEROBIC EXERCISE; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; CELLULAR-RESPONSES; SWIMMING EXERCISE; PHYSICAL-EXERCISE; RENAL INJURY; DISEASE; RATS;
D O I
10.1007/s11033-022-07122-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In patients with kidney injury, muscle mass and strength decrease with altered muscle protein synthesis and degradation along with complications such as inflammation and low physical activity. A treatment strategy to maintain muscle metabolism in kidney injury is important. One of the proposed strategies in this regard is exercise, which in addition to inducing muscle hypertrophy, reducing plasma creatinine and urea and decreasing the severity of tubal injuries, can boost immune function and has anti-inflammatory effects. One of the molecules that have been considered as a target in the treatment of many diseases is silent information regulator 1 (SIRT1). Exercise increases the expression of SIRT1 and improves its activity. Therefore, studies that examined the effect of exercise on kidney injury considering the role of SIRT1 in this effect were reviewed to determine the direction of kidney injury research in future regarding to its prevalence, especially following diabetes, and lack of definitive treatment. In this review, we found that SIRT1 can be one of renoprotective target pathways of exercise. However, further studies are needed to determine the role of SIRT1 in different kidney injuries following exercise according to the type and severity of exercise, and the type of kidney injury.
引用
收藏
页码:4025 / 4038
页数:14
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