The objective of this work which is based on a case study, it is to describe processes of self-regulation of learning in relation to neurodidactics, by taking as reality the needs of students who are studying in higher basic education of the Ecuadorian educational system, where adolescents live their own learning experiences and at the same time they develop several skills, attitudes and behaviors. The application of qualitative research methodology allowed recognizing the problem, identifying its causes and besides it let to present solution options. The established objectives allowed to determine the contributions of neuroscience- neurodidactics to the field of education, and to describe strategies that guide processes of self-regulation learning related to neurodidactic in adolescents. The contribution of researchers with a holistic approach focuses on the subjects who learn, in the case of teachers by integrating new methodologies or tools in the teaching-learning process, and in the case of students, how they can establish their self-control in individual /collaborative autonomous activities.