Prefrontal Parvalbumin Neurons in Control of Attention

被引：314

作者：

Kim, Hoseok ^{[1
]}

Ahrlund-Richter, Sofie ^{[1
]}

Wang, Xinming ^{[1
]}

Deisseroth, Karl ^{[2
,3
,4
]}

Carlen, Marie ^{[1
]}

机构：

[1] Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden

[2] Stanford Univ, Howard Hughes Med Inst, Clark Ctr W080, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Bioengn, Clark Ctr W080, Stanford, CA 94305 USA

[4] Stanford Univ, Dept Psychiat & Behav Sci, Clark Ctr W080, Stanford, CA 94305 USA

来源：

CELL | 2016年 / 164卷 / 1-2期

基金：

欧洲研究理事会;

关键词：

GAMMA-BAND SYNCHRONIZATION; REACTION-TIME-TASK; TOP-DOWN CONTROL; CORTICAL CIRCUITS; VISUAL-CORTEX; INTERNEURON DYSFUNCTION; PREPARATORY ATTENTION; SENSORY PERCEPTION; CINGULATE CORTEX; LONG-RANGE;

D O I：

10.1016/j.cell.2015.11.038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

While signatures of attention have been extensively studied in sensory systems, the neural sources and computations responsible for top-down control of attention are largely unknown. Using chronic recordings in mice, we found that fast-spiking parvalbumin (FS-PV) interneurons in medial prefrontal cortex (mPFC) uniformly show increased and sustained firing during goal-driven attentional processing, correlating to the level of attention. Elevated activity of FS-PV neurons on the timescale of seconds predicted successful execution of behavior. Successful allocation of attention was characterized by strong synchronization of FS-PV neurons, increased gamma oscillations, and phase locking of pyramidal firing. Phase-locked pyramidal neurons showed gamma-phase-dependent rate modulation during successful attentional processing. Optogenetic silencing of FS-PV neurons deteriorated attentional processing, while optogenetic synchronization of FS-PV neurons at gamma frequencies had pro-cognitive effects and improved goal-directed behavior. FS-PV neurons thus act as a functional unit coordinating the activity in the local mPFC circuit during goal-driven attentional processing.

引用

页码：208 / 218

页数：11

共 50 条

[21] Temporally Specific Roles of Ventral Tegmental Area Projections to the Nucleus Accumbens and Prefrontal Cortex in Attention and Impulse Control [J].

Flores-Dourojeanni, Jacques P. ;

van Rijt, Coby ;

van den Munkhof, Marleen H. ;

Boekhoudt, Linde ;

Luijendijk, Mieneke C. M. ;

Vanderschuren, Louk J. M. J. ;

Adan, Roger A. H. .

JOURNAL OF NEUROSCIENCE, 2021, 41 (19) :4293-4304

[22] Serotonin and Prefrontal Cortex Function: Neurons, Networks, and Circuits [J].

Puig, M. Victoria ;

Gulledge, Allan T. .

MOLECULAR NEUROBIOLOGY, 2011, 44 (03) :449-464

[23] Parvalbumin-Expressing GABAergic Neurons in Mouse Barrel Cortex Contribute to Gating a Goal-Directed Sensorimotor Transformation [J].

Sachidhanandam, Shankar ;

Sermet, B. Semihcan ;

Petersen, Carl C. H. .

CELL REPORTS, 2016, 15 (04) :700-706

[24] Top-Down Control of Visual Attention by the Prefrontal Cortex. Functional Specialization and Long-Range Interactions [J].

Paneri, Sofia ;

Gregoriou, Georgia G. .

FRONTIERS IN NEUROSCIENCE, 2017, 11

[25] Visual attention: Linking prefrontal sources to neuronal and behavioral correlates [J].

Clark, Kelsey ;

Squire, Ryan Fox ;

Merrikhi, Yaser ;

Noudoost, Behrad .

PROGRESS IN NEUROBIOLOGY, 2015, 132 :59-80

[26] No relative expansion of the number of prefrontal neurons in primate and human evolution [J].

Gabi, Mariana ;

Neves, Kleber ;

Masseron, Carolinne ;

Ribeiro, Pedro F. M. ;

Ventura-Antunes, Lissa ;

Torres, Laila ;

Mota, Bruno ;

Kaas, Jon H. ;

Herculano-Houzel, Suzana .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (34) :9617-9622

[27] Zincergic innervation of medial prefrontal cortex by basolateral projection neurons [J].

Cunningham, Miles G. ;

Ames, Heather M. ;

Christensen, Mette-Kirstine ;

Sorensen, Jens Christian .

NEUROREPORT, 2007, 18 (06) :531-535

[28] The p75 Neurotrophin Receptor in Preadolescent Prefrontal Parvalbumin Interneurons Promotes Cognitive Flexibility in Adult Mice [J].

Chehrazi, Pegah ;

Lee, Karen Ka Yan ;

Lavertu-Jolin, Marisol ;

Abbasnejad, Zahra ;

Carreno-Munoz, Maria Isabel ;

Chattopadhyaya, Bidisha ;

Di Cristo, Graziella .

BIOLOGICAL PSYCHIATRY, 2023, 94 (04) :310-321

[29] Prefrontal circuit organization for executive control [J].

Kamigaki, Tsukasa .

NEUROSCIENCE RESEARCH, 2019, 140 :23-36

[30] Prefrontal contributions to action control in rodents [J].

Hardung, Stefanie ;

Jaeckel, Zoe ;

Diester, Ilka .

WHAT DOES MEDIAL FRONTAL CORTEX SIGNAL DURING BEHAVIOR?: INSIGHTS FROM BEHAVIORAL NEUROPHYSIOLOGY, 2021, 158 :373-393

← 1 2 3 4 5 →