Revisiting the Correlate of Reduced HIV Infection Risk in the Rv144 Vaccine Trial

被引：7

作者：

Zolla-Pazner, Susan ^{[1
]}

Gilbert, Peter B. ^{[2
,3
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Med, Div Infect Dis, New York, NY 10029 USA

[2] Univ Washington, Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98195 USA

[3] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

来源：

JOURNAL OF VIROLOGY | 2019年 / 93卷 / 17期

关键词：

HIV; V1V2; domain; vaccine; antibodies; immune correlates; EFFICACY TRIAL; PROTECTIVE EFFICACY; ENVELOPE PROTEIN; DESIGN ISSUES; PHASE; 2B; ANTIBODIES; ACQUISITION; RECOMBINANT; CHALLENGES; PREVENTION;

D O I：

10.1128/JVI.00629-19

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The RV144 vaccine trial is the only clinical study to have shown a modest but statistically significant decrease in HIV infection risk. RV144 and the subsequent studies identifying the level of V1V2-specific antibodies as a correlate of reduced infection risk are still controversial despite many papers supporting and expanding the initial study. We address these controversies and summarize active-immunization and passive-immunization experiments in nonhuman primates that support the initial finding.

引用

页数：6

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