Increased serum levels of sortilin are associated with depression and correlated with BDNF and VEGF

被引:40
作者
Buttenschon, H. N. [1 ,2 ]
Demontis, D. [2 ,3 ,4 ]
Kaas, M. [5 ]
Elfving, B. [1 ]
Molgaard, S. [5 ]
Gustafsen, C. [5 ]
Kaerlev, L. [6 ,7 ]
Petersen, C. M. [5 ]
Borglum, A. D. [2 ,3 ,4 ]
Mors, O. [2 ,8 ]
Glerup, S. [5 ]
机构
[1] Aarhus Univ, Dept Clin Med, Translat Neuropsychiat Unit, iPSYCH, Skovagervej 2, DK-8240 Risskov, Denmark
[2] Lundbeck Fdn Initiat Integrat Psychiat Res, iPSYCH, Aarhus, Denmark
[3] Aarhus Univ, Dept Biomed, iPSYCH, DK-8240 Risskov, Denmark
[4] Aarhus Univ, Ctr Integrat Sequencing, iPSYCH, DK-8240 Risskov, Denmark
[5] Aarhus Univ, MIND, Lundbeck Fdn Res Ctr, iPSYCH, DK-8240 Risskov, Denmark
[6] Univ Southern Denmark, Inst Clin Res, Res Unit Clin Epidemiol, Odense, Denmark
[7] Odense Univ Hosp, Ctr Clin Epidemiol, DK-5000 Odense, Denmark
[8] Aarhus Univ Hosp, Res Dept P, iPSYCH, DK-8000 Aarhus, Denmark
关键词
GENOME-WIDE ASSOCIATION; THREATENING EXPERIENCES; NEUROTROPHIC FACTOR; BRAIN; RISK; PROBDNF; LIST; AGE;
D O I
10.1038/tp.2015.167
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Neurotrophic factors have been investigated in relation to depression. The aim of the present study was to widen this focus to sortilin, a receptor involved in neurotrophic signalling. The serum sortilin level was investigated in 152 individuals with depression and 216 control individuals, and eight genetic markers located within the SORT1 gene were successfully analysed for association with depression. Genotyping was performed using the Sequenom MassARRAY platform. All the individuals returned a questionnaire and participated in a semi-structured diagnostic interview. Sortilin levels were measured by immunoassay, and potential determinants of the serum sortilin level were assessed by generalized linear models. Serum levels of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) were measured in previous studies. We identified a significant increase of serum sortilin levels in depressed individuals compared with controls (P = 0.0002) and significant positive correlation between serum sortilin levels and the corresponding levels of BDNF and VEGF. None of the genotyped SNPs were associated with depression. Additional analyses showed that the serum sortilin level was influenced by several other factors. Alcohol intake and body mass index, as well as depression, serum BDNF and serum VEGF were identified as predictors of serum sortilin levels in our final multivariate model. In conclusion, the results suggest a role of circulating sortilin in depression which may relate to altered activity of neurotrophic factors.
引用
收藏
页码:e677 / e677
页数:7
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