Microsomal prostaglandin E synthase protein levels correlate with prognosis in colorectal cancer patients

被引：32

作者：

Seo, Tsuguhiko ^{[1
]}

Tatsuguchi, Atsushi ^{[1
,2
]}

Shinji, Seiichi ^{[3
]}

Yonezawa, Masaoki ^{[1
]}

Mitsui, Keigo ^{[1
]}

Tanaka, Shu ^{[1
]}

Fujimori, Shunji ^{[1
]}

Gudis, Katya ^{[1
]}

Fukuda, Yuh ^{[2
]}

Sakamoto, Choitsu ^{[1
]}

机构：

[1] Nippon Med Sch, Div Gastroenterol, Dept Med, Bunkyo Ku, Tokyo 1138603, Japan

[2] Nippon Med Sch, Dept Analyt Human Pathol, Bunkyo Ku, Tokyo 1138602, Japan

[3] Nippon Med Sch, Grad Sch Med, Dept Surg 1, Bunkyo Ku, Tokyo 1138603, Japan

来源：

VIRCHOWS ARCHIV | 2009年 / 454卷 / 06期

关键词：

Colorectal neoplasm; Cyclooxygenase-2; Prognosis; Prostaglandin E synthase; Immunohistochemistry; CYCLOOXYGENASE-2; EXPRESSION; E-2; BIOSYNTHESIS; INTESTINAL TUMORIGENESIS; INTERFERON-GAMMA; GENETIC DELETION; TISSUE; PREVENTION; CELECOXIB; IDENTIFICATION; CELLS;

D O I：

10.1007/s00428-009-0777-z

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The aim of this study is to investigate the expression of three prostaglandin E synthase (PGES) isomers in colorectal cancer (CRC) tissue and to evaluate their relationship to clinicopathological factors and patient prognosis. Microsomal PGES (mPGES)-1, mPGES-2, cytosolic PGES (cPGES) and cyclooxygenase (COX)-2 protein expression were analyzed by real-time polymerase chain reaction and Western blot. The localization of each PGES and COX-2 protein was examined by immunohistochemistry in 155 surgical resections and correlated to clinicopathological factors and patient prognosis. mPGES-1 mRNA and protein levels were significantly higher in CRC than in paired normal tissues. mPGES-1 immunoreactivity localized in cancer cells in 43% of cases. mPGES-2 immunoreactivity was significantly more pronounced in cancer cells than in adjacent normal epithelium in 36% of cases. cPGES immunoreactivity was homogeneous in cancer cells and thus determined constitutive. mPGES-1 and mPGES-2 correlated with significantly worse prognosis in stage I-III patients. These results indicate that mPGES-1 and mPGES-2 may each play a role in CRC progression.

引用

页码：667 / 676

页数：10

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