Drug Conjugation to Cyclic Peptide-Polymer Self-Assembling Nanotubes

被引：41

作者：

Blunden, Bianca M. ^{[1
,2
]}

Chapman, Robert ^{[3
]}

Danial, Maarten ^{[3
]}

Lu, Hongxu ^{[1
]}

Jolliffe, Katrina A. ^{[4
]}

Perrier, Sebastien ^{[3
,5
,6
]}

Stenzel, Martina H. ^{[1
]}

机构：

[1] Univ New S Wales, Sch Chem, Ctr Adv Macromol Design, Sydney, NSW 2052, Australia

[2] Cooperat Res Ctr CRC Polymers, Notting Hill, Vic 3618, Australia

[3] Univ Sydney, Sch Chem, Key Ctr Polymers & Colloids, Sydney, NSW 2006, Australia

[4] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

[5] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[6] Monash Univ, Fac Pharm & Pharmaceut Sci, Parkville, Vic 3052, Australia

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 40期

基金：

澳大利亚研究理事会;

关键词：

drug conjugation; nanotubes; peptides; ruthenium; self-assembly; BREAST-CANCER; RUTHENIUM; DELIVERY; DESIGN; COMPLEXES; COMPOUND; SHAPE; PTA;

D O I：

10.1002/chem.201403130

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We show for the first time how polymeric nano-tubes (NTs) based on self-assembled conjugates of polymers and cyclic peptides can be used as an efficient drug carrier. RAPTA-C, a ruthenium-based anticancer drug, was conjugated to a statistical co-polymer based on poly(2-hydroxyethyl acrylate) (pHEA) and poly(2-chloroethyl methacrylate) (pCEMA), which formed the shell of the NTs. Self-assembly into nanotubes (length 200-500 nm) led to structures exhibiting high activity against cancer cells.

引用

页码：12745 / 12749

页数：5

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