Drug Conjugation to Cyclic Peptide-Polymer Self-Assembling Nanotubes

被引：41
|
作者：
Blunden, Bianca M. [1 ,2 ]
Chapman, Robert [3 ]
Danial, Maarten [3 ]
Lu, Hongxu [1 ]
Jolliffe, Katrina A. [4 ]
Perrier, Sebastien [3 ,5 ,6 ]
Stenzel, Martina H. [1 ]
机构：
[1] Univ New S Wales, Sch Chem, Ctr Adv Macromol Design, Sydney, NSW 2052, Australia
[2] Cooperat Res Ctr CRC Polymers, Notting Hill, Vic 3618, Australia
[3] Univ Sydney, Sch Chem, Key Ctr Polymers & Colloids, Sydney, NSW 2006, Australia
[4] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia
[5] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England
[6] Monash Univ, Fac Pharm & Pharmaceut Sci, Parkville, Vic 3052, Australia
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 40期
基金：
澳大利亚研究理事会;
关键词：
drug conjugation; nanotubes; peptides; ruthenium; self-assembly; BREAST-CANCER; RUTHENIUM; DELIVERY; DESIGN; COMPLEXES; COMPOUND; SHAPE; PTA;
D O I：
10.1002/chem.201403130
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We show for the first time how polymeric nano-tubes (NTs) based on self-assembled conjugates of polymers and cyclic peptides can be used as an efficient drug carrier. RAPTA-C, a ruthenium-based anticancer drug, was conjugated to a statistical co-polymer based on poly(2-hydroxyethyl acrylate) (pHEA) and poly(2-chloroethyl methacrylate) (pCEMA), which formed the shell of the NTs. Self-assembly into nanotubes (length 200-500 nm) led to structures exhibiting high activity against cancer cells.
引用
收藏
页码：12745 / 12749
页数：5
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