A little bit of kindlin goes a long way

被引：1

作者：

Bennett, Joel S. ^{[1
]}

机构：

[1] Univ Penn, Philadelphia, PA 19104 USA

来源：

BLOOD | 2015年 / 126卷 / 24期

关键词：

INTEGRIN ACTIVATION; ALPHA-IIB-BETA-3; MECHANISM; TALIN;

D O I：

10.1182/blood-2015-10-675454

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this issue of Blood, Klapproth et al used mice that were hypomorphic for the protein kindlin-3 to demonstrate that as little as 5% of the normal amount of kindlin-3 is sufficient to protect against spontaneous bleeding and infection.

引用

页码：2535 / 2536

页数：2

共 11 条

[1] Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: Implications for talin activation [J].

Goult, Benjamin T. ;

Xu, Xiao-Ping ;

Gingras, Alexandre R. ;

Swift, Mark ;

Patel, Bipin ;

Bate, Neil ;

Kopp, Petra M. ;

Barsukov, Igor L. ;

Critchley, David R. ;

Volkmann, Niels ;

Hanein, Dorit .

JOURNAL OF STRUCTURAL BIOLOGY, 2013, 184 (01) :21-32

[2] The kindlins at a glance [J].

Karakoese, Esra ;

Schiller, Herbert B. ;

Faessler, Reinhard .

JOURNAL OF CELL SCIENCE, 2010, 123 (14) :2353-2356

[3] Minimal amounts of kindlin-3 suffice for basal platelet and leukocyte functions in mice [J].

Klapproth, Sarah ;

Moretti, Federico A. ;

Zeiler, Marlis ;

Ruppert, Raphael ;

Breithaupt, Ute ;

Mueller, Susanna ;

Haas, Rainer ;

Mann, Matthias ;

Sperandio, Markus ;

Faessler, Reinhard ;

Moser, Markus .

BLOOD, 2015, 126 (24) :2592-2600

[4] LAD-1/variant syndrome is caused by mutations in FERMT3 [J].

Kuijpers, Taco W. ;

van de Vijver, Edith ;

Weterman, Marian A. J. ;

de Boer, Martin ;

Tool, Anton T. J. ;

van den Berg, Timo K. ;

Moser, Markus ;

Jakobs, Marja E. ;

Seeger, Karl ;

Sanal, Oezden ;

Uenal, Sule ;

Cetin, Mualla ;

Roos, Dirk ;

Verhoeven, Arthur J. ;

Baas, Frank .

BLOOD, 2009, 113 (19) :4740-4746

[5] Structural Basis of Phosphoinositide Binding to Kindlin-2 Protein Pleckstrin Homology Domain in Regulating Integrin Activation [J].

Liu, Jianmin ;

Fukuda, Koichi ;

Xu, Zhen ;

Ma, Yan-Qing ;

Hirbawi, Jamila ;

Mao, Xian ;

Wu, Chuanyue ;

Plow, Edward F. ;

Qin, Jun .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (50) :43334-43342

[6] A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans [J].

Malinin, Nikolay L. ;

Zhang, Li ;

Choi, Jeongsuk ;

Ciocea, Alieta ;

Razorenova, Olga ;

Ma, Yan-Qing ;

Podrez, Eugene A. ;

Tosi, Michael ;

Lennon, Donald P. ;

Caplan, Arnold I. ;

Shurin, Susan B. ;

Plow, Edward F. ;

Byzova, Tatiana V. .

NATURE MEDICINE, 2009, 15 (03) :313-318

[7] NMR analysis of the αIIbβ3 cytoplasmic interaction suggests a mechanism for integrin regulation [J].

Metcalf, Douglas G. ;

Moore, David T. ;

Wu, Yibing ;

Kielec, Joseph M. ;

Molnar, Kathleen ;

Valentine, Kathleen G. ;

Wand, A. Joshua ;

Bennett, Joel S. ;

DeGrado, William F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (52) :22481-22486

[8] The Tail of Integrins, Talin, and Kindlins [J].

Moser, Markus ;

Legate, Kyle R. ;

Zent, Roy ;

Faessler, Reinhard .

SCIENCE, 2009, 324 (5929) :895-899

[9] Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models [J].

Nurden, Alan T. ;

Fiore, Mathieu ;

Nurden, Paquita ;

Pillois, Xavier .

BLOOD, 2011, 118 (23) :5996-6005

[10] The Mechanism of Kindlin-Mediated Activation of Integrin αIIbβ3 [J].

Ye, Feng ;

Petrich, Brian G. ;

Anekal, Praju ;

Lefort, Craig T. ;

Kasirer-Friede, Ana ;

Shattil, Sanford J. ;

Ruppert, Raphael ;

Moser, Markus ;

Faessler, Reinhard ;

Ginsberg, Mark H. .

CURRENT BIOLOGY, 2013, 23 (22) :2288-2295

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