The nucleophilic addition of α-metallated 1,3-dioxanes to planar chiral cationic η3-allylmolybdenum complexes.: Synthesis of (2E,5S,6R,7E)-6-methyl-8-phenylocta-2,7-dienoic acid methyl ester, a key component of the Cryptophycins

被引：26

作者：

Cooksey, J

Gunn, A

Kocienski, PJ ^{[1
]}

Kuhl, A

Uppal, S

Christopher, JA

Bell, R

机构：

[1] Univ Leeds, Dept Chem, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland

[3] GlaxoSmithKline Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2004年 / 2卷 / 12期

关键词：

D O I：

10.1039/b400242c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two adjacent stereogenic centres and a pendant alkene were constructed via nucleophilic addition of a 1,3-dioxan-4-ylcopper(I) reagent to a cationic eta(3)-allylmolybdenum complex as part of a synthesis of (2E,5S,6R,7E)-6-methyl-8-phenylocta-2,7-dienoic acid, a key component of the Cryptophycins. Oxidative addition of Mo(CO)(4)(THF)(2) to allyl benzoates provides an efficient synthesis of eta(3)-allylmolybdenum(dicarbonyl) complexes.

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页码：1719 / 1731

页数：13

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