Pyrrolo[2,3-d]pyrimidine derivatives in the synthesis of a novel heterocyclic system 2a,5a,7-triazaacenaphthylene

被引：1

作者：

Muzychka, Lyubov V. ^{[1
]}

Yaremchuk, Iryna O. ^{[1
]}

Verves, Evgenii V. ^{[1
]}

Smolii, Oleg B. ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, VP Kukhar Inst Bioorgan Chem & Petrochem, 1 Murmanska St, UA-02094 Kiev, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2019年 / 55卷 / 4-5期

关键词：

pyrimido[5'; 4':4; 5]pyrrolo[2; 1-c][1; 4]oxazine; pyrrolo[2; 3-d]pyrimidine; 2a; 5a; 7-triazaacenaphthylene; cyclization; iodination; INHIBITOR; POTENT;

D O I：

10.1007/s10593-019-02471-z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient method for the synthesis of methyl 8-oxo-3H,8H-2a,5a,7-triazaacenaphthylene-2-carboxylate by iodination of 7-allyl-4-methoxypyrrolo[2,3-d]pyrimidine-6-carboxylic acid methyl ester followed by elimination of hydrogen iodide has been developed. The use of 4-methoxypyrrolo[2,3-d]pyrimidine-6-carboxylic acid as the starting compound led to the formation of iodomethylpyrimido[5',4':4,5]-pyrrolo[2,1-c][1,4]oxazine, a promising precursor for the synthesis of a new tricyclic system based on pyrrolo[2,3-d]pyrimidine.

引用

页码：397 / 400

页数：4

共 13 条

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