Cisplatin and paclitaxel target significant long noncoding RNAs in laryngeal squamous cell carcinoma

被引：68

作者：

Chen, Hui ^{[1
]}

Xin, Yuan ^{[1
]}

Zhou, Liang ^{[1
]}

Huang, Jia-meng ^{[1
]}

Tao, Lei ^{[1
]}

Cheng, Lei ^{[1
]}

Tian, Jie ^{[2
]}

机构：

[1] Fudan Univ, Dept Otolaryngol Head & Neck Surg, Affiliated Eye & ENT Hosp, Shanghai 200031, Peoples R China

[2] Fudan Univ, Cent Lab, Affiliated Eye & ENT Hosp, Shanghai 200031, Peoples R China

来源：

MEDICAL ONCOLOGY | 2014年 / 31卷 / 11期

关键词：

Long noncoding RNA; Cisplatin; Paclitaxel; Target; Laryngeal squamous cell carcinoma; CLIP-SEQ; EXPRESSION; LOCUS; GENE; METASTASIS; APOPTOSIS; HOTAIR; MEG3; IDENTIFICATION; PROLIFERATION;

D O I：

10.1007/s12032-014-0246-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The objectives of this study were to identify specific long noncoding RNAs (lncRNAs) in laryngeal squamous cell carcinoma (LSCC) and to clarify the function of cisplatin and paclitaxel on the confirmed laryngeal cancer lncRNAs. Fifty-four pairs of laryngeal tumor and adjacent normal tissue were collected. Candidate lncRNAs were searched in authorized databases. The significant lncRNAs were identified and confirmed through high-output real-time PCR. Chemotherapy assay evaluated the influences of cisplatin and paclitaxel on the significant lncRNAs. Thirty-seven cancer-related candidate lncRNAs were selected. Three up-expressed and two down-expressed significant lncRNAs were identified and confirmed. The expressions of lncRNA CDKN2B-AS1, HOTAIR and MALAT1 were dramatically reduced with the increasing concentration of cisplatin and paclitaxel and also lengthening of the treatment duration. Cisplatin and paclitaxel have target function on significant lncRNAs in LSCC, which presents novel molecular targets to cure LSCC patients and also leads an orientation for developing new drugs.

引用

页数：13

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