Prognostic use of soluble fms-like tyrosine kinase-1 and placental growth factor in patients with coronary artery disease

被引：8
作者：
Sinning, Christoph [1 ]
Schnabel, Renate B. [1 ]
Zeller, Tanja [1 ]
Seiffert, Moritz [1 ]
Rupprecht, Hans J. [2 ]
Lackner, Karl J. [3 ]
Blankenberg, Stefan [1 ]
Bickel, Christoph [4 ]
Westermann, Dirk [1 ]
机构：
[1] Univ Heart Ctr Hamburg, Dept Gen & Intervent Cardiol, Hamburg, Germany
[2] GPR Klinikum Russelsheim, Dept Internal Med 2, Hamburg, Germany
[3] Johannes Gutenberg Univ Mainz, Dept Clin Chem & Lab Med, Mainz, Germany
[4] Fed Armed Forces Cent Hosp, Dept Internal Med, Koblenz, Germany
来源：
BIOMARKERS IN MEDICINE | 2016年 / 10卷 / 01期
关键词：
angiogenesis; coronary artery disease; placental growth factor; soluble fms-like tyrosine kinase-1; vascular endothelial growth factor; ACUTE MYOCARDIAL-INFARCTION; CHRONIC HEART-FAILURE; ADVERSE OUTCOMES; ANGIOGENESIS; EXPRESSION; ATHEROSCLEROSIS; RISK; RECEPTOR; REVASCULARIZATION; IMPROVEMENT;
D O I：
10.2217/bmm.15.111
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background: Intention of the study is to assess the cardiovascular mortality of patients with coronary artery disease (CAD) with the biomarkers of angiogenesis PlGF and its endogenous inhibitor sFlt-1. Methods: The cohort included n = 1848 patients with CAD and 282 subjects without CAD. In 85 patients cardiovascular mortality, as combination of fatal myocardial infarction or any cardiac death, during a median follow-up duration of 3.9 years was reported. Results: In Kaplan-Meier curve analysis PlGF in rising thirds was not predictive regarding outcome (p = 0.54), the same was shown for sFlt-1 (p = 0.44). Cox regression for the fully adjusted model provided a hazard ratio (HR) of 0.8 (p = 0.18) for PlGF and for sFlt-1 a HR = 1.0 (p = 0.8). Conclusion: Our results point out that these biomarkers reflecting angiogenesis might not be suited to establish prognosis in CAD.
引用
收藏
页码：95 / 106
页数：12
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