Prognostic use of soluble fms-like tyrosine kinase-1 and placental growth factor in patients with coronary artery disease

被引：8
作者：
Sinning, Christoph [1 ]
Schnabel, Renate B. [1 ]
Zeller, Tanja [1 ]
Seiffert, Moritz [1 ]
Rupprecht, Hans J. [2 ]
Lackner, Karl J. [3 ]
Blankenberg, Stefan [1 ]
Bickel, Christoph [4 ]
Westermann, Dirk [1 ]
机构：
[1] Univ Heart Ctr Hamburg, Dept Gen & Intervent Cardiol, Hamburg, Germany
[2] GPR Klinikum Russelsheim, Dept Internal Med 2, Hamburg, Germany
[3] Johannes Gutenberg Univ Mainz, Dept Clin Chem & Lab Med, Mainz, Germany
[4] Fed Armed Forces Cent Hosp, Dept Internal Med, Koblenz, Germany
来源：
BIOMARKERS IN MEDICINE | 2016年 / 10卷 / 01期
关键词：
angiogenesis; coronary artery disease; placental growth factor; soluble fms-like tyrosine kinase-1; vascular endothelial growth factor; ACUTE MYOCARDIAL-INFARCTION; CHRONIC HEART-FAILURE; ADVERSE OUTCOMES; ANGIOGENESIS; EXPRESSION; ATHEROSCLEROSIS; RISK; RECEPTOR; REVASCULARIZATION; IMPROVEMENT;
D O I：
10.2217/bmm.15.111
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background: Intention of the study is to assess the cardiovascular mortality of patients with coronary artery disease (CAD) with the biomarkers of angiogenesis PlGF and its endogenous inhibitor sFlt-1. Methods: The cohort included n = 1848 patients with CAD and 282 subjects without CAD. In 85 patients cardiovascular mortality, as combination of fatal myocardial infarction or any cardiac death, during a median follow-up duration of 3.9 years was reported. Results: In Kaplan-Meier curve analysis PlGF in rising thirds was not predictive regarding outcome (p = 0.54), the same was shown for sFlt-1 (p = 0.44). Cox regression for the fully adjusted model provided a hazard ratio (HR) of 0.8 (p = 0.18) for PlGF and for sFlt-1 a HR = 1.0 (p = 0.8). Conclusion: Our results point out that these biomarkers reflecting angiogenesis might not be suited to establish prognosis in CAD.
引用
收藏
页码：95 / 106
页数：12
相关论文
共 38 条
  • [1] Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders
    Autiero, M
    Luttun, A
    Tjwa, M
    Carmeliet, P
    [J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2003, 1 (07) : 1356 - 1370
  • [2] Measurement of free and complexed soluble vascular endothelial growth factor receptor, Flt-I, in fluid samples: development and application of two new immunoassays
    Belgore, FM
    Blann, AD
    Lip, GY
    [J]. CLINICAL SCIENCE, 2001, 100 (05) : 567 - 575
  • [3] Elevated concentration of placental growth factor (PlGF) and long term risk in patients with acute coronary syndrome in the PROVE IT-TIMI 22 trial
    Bui, An H.
    Bonaca, Marc P.
    Sabatine, Marc S.
    Ray, Kausik K.
    Rifai, Nader
    Cannon, Christopher P.
    Morrow, David A.
    [J]. JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2012, 34 (02) : 222 - 228
  • [4] Immunohistochemical expression of vascular endothelial growth factor vascular permeability factor in atherosclerotic intimas of human coronary arteries
    Chen, YX
    Nakashima, Y
    Tanaka, K
    Shiraishi, S
    Nakagawa, K
    Sueishi, K
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (01) : 131 - 139
  • [5] Angiogenesis, thrombogenesis, endothelial dysfunction and angiographic severity of coronary artery disease
    Chung, NA
    Lydakis, C
    Belgore, F
    Li-Saw-Hee, FL
    Blann, AD
    Lip, GYH
    [J]. HEART, 2003, 89 (12) : 1411 - 1415
  • [6] Angiogenesis in myocardial infarction - An acute or chronic process?
    Chung, NAY
    Lydakis, C
    Belgore, F
    Blann, AD
    Lip, GYH
    [J]. EUROPEAN HEART JOURNAL, 2002, 23 (20) : 1604 - 1608
  • [7] Structure and function of placental growth factor
    De Falco, S
    Gigante, B
    Persico, MG
    [J]. TRENDS IN CARDIOVASCULAR MEDICINE, 2002, 12 (06) : 241 - 246
  • [8] COMPARING THE AREAS UNDER 2 OR MORE CORRELATED RECEIVER OPERATING CHARACTERISTIC CURVES - A NONPARAMETRIC APPROACH
    DELONG, ER
    DELONG, DM
    CLARKEPEARSON, DI
    [J]. BIOMETRICS, 1988, 44 (03) : 837 - 845
  • [9] Myocardial infarction accelerates atherosclerosis
    Dutta, Partha
    Courties, Gabriel
    Wei, Ying
    Leuschner, Florian
    Gorbatov, Rostic
    Robbins, Clinton S.
    Iwamoto, Yoshiko
    Thompson, Brian
    Carlson, Alicia L.
    Heidt, Timo
    Majmudar, Maulik D.
    Lasitschka, Felix
    Etzrodt, Martin
    Waterman, Peter
    Waring, Michael T.
    Chicoine, Adam T.
    van der Laan, Anja M.
    Niessen, Hans W. M.
    Piek, Jan J.
    Rubin, Barry B.
    Butany, Jagdish
    Stone, James R.
    Katus, Hugo A.
    Murphy, Sabina A.
    Morrow, David A.
    Sabatine, Marc S.
    Vinegoni, Claudio
    Moskowitz, Michael A.
    Pittet, Mikael J.
    Libby, Peter
    Lin, Charles P.
    Swirski, Filip K.
    Weissleder, Ralph
    Nahrendorf, Matthias
    [J]. NATURE, 2012, 487 (7407) : 325 - 329
  • [10] THE MEANING AND USE OF THE AREA UNDER A RECEIVER OPERATING CHARACTERISTIC (ROC) CURVE
    HANLEY, JA
    MCNEIL, BJ
    [J]. RADIOLOGY, 1982, 143 (01) : 29 - 36
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