One-pot synthesis of tryptanthrin by the Dakin oxidation of indole-3-carbaldehyde

被引：40

作者：

Abe, Takumi ^{[1
]}

Itoh, Tomoki ^{[1
]}

Choshi, Tominari ^{[2
]}

Hibino, Satoshi ^{[2
]}

Ishikura, Minoru ^{[1
]}

机构：

[1] Hlth Sci Univ Hokkaido, Sch Pharmaceut Sci, Ishikari, Hokkaido 0610293, Japan

[2] Fukuyama Univ, Fac Pharm & Pharmaceut Sci, Fukuyama, Hiroshima 7290292, Japan

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 38期

关键词：

Oxidative coupling; Indole-3-carbaldehyde; Indolo[2,1-b]quinazoline; Urea hydrogen peroxide; Dakin oxidation; DERIVATIVES; CANDIDINE; ALKALOIDS; INDOLES; ANALOGS; AGENTS;

D O I：

10.1016/j.tetlet.2014.07.113

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot approach to indolo[2,1-b]quinazolines from indole-3-carbaldehydes through the Dakin oxidation was developed. It was shown that the reaction proceeded through the condensation of indole-3-carbaldehydes with isatoic anhydrides, derived in situ from indole-3-carbaldehydes by the Dakin oxidation, and further oxidation/cyclization steps. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：5268 / 5270

页数：3

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