Self-tolerance of natural killer cells

被引：431
作者：
Raulet, David H. [1 ]
Vance, Russell E. [1 ]
机构：
[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Canc Res Lab, Berkeley, CA 94720 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 07期
关键词：
D O I：
10.1038/nri1863
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Natural killer (NK) cells, similar to other lymphocytes, acquire tolerance to self. This means that NK cells have the potential to attack normal self cells but that there are mechanisms to ensure that this does not usually occur. Self-tolerance is acquired by NK cells during their development, but the underlying molecular and cellular mechanisms remain poorly understood. Recent studies have produced important new information about NK-cell self-tolerance. Here, we review the evidence for and against possible mechanisms of NK-cell self-tolerance, with an emphasis on the role of MHC-specific receptors.
引用
收藏
页码：520 / 531
页数：12
相关论文
共 108 条
  • [1] Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors
    Arase, H
    Mocarski, ES
    Campbell, AE
    Hill, AB
    Lanier, LL
    [J]. SCIENCE, 2002, 296 (5571) : 1323 - 1326
  • [2] Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus
    Arnon, TI
    Achdout, H
    Levi, O
    Markel, G
    Saleh, N
    Katz, G
    Gazit, R
    Gonen-Gross, T
    Hanna, J
    Nahari, E
    Porgador, A
    Honigman, A
    Plachter, B
    Mevorach, D
    Wolf, DG
    Mandelboim, O
    [J]. NATURE IMMUNOLOGY, 2005, 6 (05) : 515 - 523
  • [3] Suppression of natural killer cell-mediated bone marrow cell rejection by CD4+CD25+ regulatory T cells
    Barao, I
    Hanash, AM
    Hallett, W
    Welniak, LA
    Sun, K
    Redelman, D
    Blazar, BR
    Levy, RB
    Murphy, WJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (14) : 5460 - 5465
  • [4] Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA
    Bauer, Stefan
    Groh, Veronika
    Wu, Jun
    Steinle, Alexander
    Phillips, Joseph H.
    Lanier, Lewis L.
    Spies, Thomas
    [J]. JOURNAL OF IMMUNOLOGY, 2018, 200 (07) : 2231 - 2233
  • [5] Natural killer cells in antiviral defense: Function and regulation by innate cytokines
    Biron, CA
    Nguyen, KB
    Pien, GC
    Cousens, LP
    Salazar-Mather, TP
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 : 189 - 220
  • [6] REJECTION OF CLASS-I MHC-DEFICIENT HEMATOPOIETIC-CELLS BY IRRADIATED MHC-MATCHED MICE
    BIX, M
    LIAO, NS
    ZIJLSTRA, M
    LORING, J
    JAENISCH, R
    RAULET, D
    [J]. NATURE, 1991, 349 (6307) : 329 - 331
  • [7] Identification of PVR (CD155) and nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule
    Bottino, C
    Castriconi, R
    Pende, D
    Rivera, P
    Nanni, M
    Carnemolla, B
    Cantoni, C
    Grassi, J
    Marcenaro, S
    Reymond, N
    Vitale, M
    Moretta, L
    Lopez, M
    Moretta, A
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (04) : 557 - 567
  • [8] HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
    Braud, VM
    Allan, DSJ
    O'Callaghan, CA
    Söderström, K
    D'Andrea, A
    Ogg, GS
    Lazetic, S
    Young, NT
    Bell, JI
    Phillips, JH
    Lanier, LL
    McMichael, AJ
    [J]. NATURE, 1998, 391 (6669) : 795 - 799
  • [9] Vital involvement of a natural killer cell activation receptor in resistance to viral infection
    Brown, MG
    Dokun, AO
    Heusel, JW
    Smith, HRC
    Beckman, DL
    Blattenberger, EA
    Dubbelde, CE
    Stone, LR
    Scalzo, AA
    Yokoyama, WM
    [J]. SCIENCE, 2001, 292 (5518) : 934 - 937
  • [10] 2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48
    Brown, MH
    Boles, K
    van der Merwe, PA
    Kumar, V
    Mathew, PA
    Barclay, AN
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (11) : 2083 - 2090
12345678910