HLA DRB1*130101-DQB1*060101 haplotype is associated with acute chest syndrome in sickle cell anemia patients

被引：7
作者：
Mahdi, N. [1 ]
Al-Subaie, A. M. [2 ]
Al-Ola, K. [1 ]
Al-Irhayim, A. Q. [2 ]
Ali, M. E. [2 ]
Al-Irhayim, Z. [2 ]
Almawi, W. Y. [2 ]
机构：
[1] Dept Pediat, Manama, Bahrain
[2] Arabian Gulf Univ, Dept Med Biochem, Coll Med & Med Sci, Manama, Bahrain
来源：
TISSUE ANTIGENS | 2009年 / 73卷 / 03期
关键词：
acute chest syndrome; Bahrain; HLA class II; PCR-SSP; sickle cell anemia; CHILDREN; DISEASE; ALLELES; COMPLICATIONS; SEVERITY; HLA-DRB1; PEPTIDE; STROKE;
D O I：
10.1111/j.1399-0039.2008.01189.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We investigated the association of human leukocyte antigens (HLA) class II alleles and haplotypes with the pathogenesis of acute chest syndrome (ACS) in 186 sickle cell anemia (SCA) patients, of whom 58 had documented ACS (new pulmonary infiltrate, fever, and other associated clinical events) and 128 with a negative history of ACS, serving as controls. HLA DRB1* and -DQB1* genotyping was performed by polymerase chain reaction-sequence-specific priming. Of the DRB1* and DQB1* alleles analyzed, only DRB1*130101 (Pc < 0.001) was positively associated with ACS. DRB1*130101-DQB1*060101 haplotype was more prevalent among ACS patients (P = 0.018), thus conferring disease susceptibility. Specific HLA alleles and haplotypes may influence ACS risk in SCA patients, and specific HLA genotypes may be useful markers for identifying high-risk SCA ACS patients.
引用
收藏
页码：245 / 249
页数：5
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