Background: Sleep apnea (SA) has been associated with cognitive impairment. However, no data regarding the risk of dementia in patients with SA has been reported in the general population. This retrospective matched-control cohort study was designed to estimate and compare the risk of dementia in SA and non-SA patients among persons aged 40 and above over a 5-year period follow-up. Methods: We conducted a nationwide 5-year population-based study using data retrieved from the Longitudinal Health Insurance Database 2005 (LHID2005) in Taiwan. The study cohort comprised 1414 patients with SA aged 40 years who had at least 1 inpatient service claim or 1 ambulatory care claim. The comparison cohort comprised 7070 randomly selected patients who were matched with the study group according to sex, age, and index year. We performed Cox proportional-hazards regressions to compute the 5-year dementia-free survival rates after adjusting for potentially confounding factors. Results: The SA patients in this study had a 1.70-times greater risk of developing dementia within 5 years of diagnosis compared to non-SA age-and sex-matched patients, after adjusting for other risk factors (95% confidence interval (CI) = 1.26-2.31; P < .01). For the gender-dependent effect, only females with SA were more likely to develop dementia (adjust HR: 2.38, 95% CI = 1.51-3.74; P < .001). For the age-dependent effect of different genders, males with SA aged 50-59 years had a 6.08 times greater risk for developing dementia (95% CI = 1.96-18.90), and females with SA aged >= 70 years had a 3.20 times greater risk of developing dementia (95% CI = 1.71-6.00). For the time-dependent effect, dementia may be most likely to occur in the first 2.5 years of follow-up (adjusted HR: 2.04, 95% CI = 1.35-3.07). Conclusions: SA may be a gender-dependent, age-dependent, and time-dependent risk factor for dementia.
机构:
Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
Vet Affairs San Diego Healthcare Syst, Res Serv, San Diego, CA USAUniv Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
Ayalon, Liat
Ancoli-Israel, Sonia
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Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USAUniv Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
Ancoli-Israel, Sonia
Drummond, Sean P. A.
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h-index: 0
机构:
Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
Vet Affairs San Diego Healthcare Syst, Psychol Serv, San Diego, CA USAUniv Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
机构:
Ist Sci San Raffaele, Div Neurosci, I-20127 Milan, Italy
Univ Vita Salute San Raffaele, CRESA, I-20127 Milan, Italy
Univ Vita Salute San Raffaele, Ctr Cognit Neurosci, I-20127 Milan, Italy
Univ Vita Salute San Raffaele, CERMAC, I-20127 Milan, ItalyUniv Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, Italy
Canessa, Nicola
Castronovo, Vincenza
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h-index: 0
机构:
Univ Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, ItalyUniv Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, Italy
Castronovo, Vincenza
Cappa, Stefano F.
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h-index: 0
机构:
Ist Sci San Raffaele, Div Neurosci, I-20127 Milan, Italy
Univ Vita Salute San Raffaele, CRESA, I-20127 Milan, Italy
Univ Vita Salute San Raffaele, Ctr Cognit Neurosci, I-20127 Milan, Italy
Univ Vita Salute San Raffaele, CERMAC, I-20127 Milan, ItalyUniv Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, Italy
Cappa, Stefano F.
Aloia, Mark S.
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h-index: 0
机构:
Natl Jewish Med & Res Ctr, Dept Med, Denver, CO USAUniv Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, Italy
Aloia, Mark S.
Marelli, Sara
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h-index: 0
机构:
Univ Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, ItalyUniv Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, Italy
Marelli, Sara
Falini, Andrea
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vita Salute San Raffaele, Neuroradiol Unit, I-20127 Milan, Italy
Univ Vita Salute San Raffaele, CERMAC, I-20127 Milan, ItalyUniv Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, Italy
Falini, Andrea
Alemanno, Federica
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机构:
Ist Sci San Raffaele, Div Neurosci, I-20127 Milan, Italy
Univ Vita Salute San Raffaele, Ctr Cognit Neurosci, I-20127 Milan, Italy
Univ Vita Salute San Raffaele, CERMAC, I-20127 Milan, ItalyUniv Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, Italy
Alemanno, Federica
Ferini-Strambi, Luigi
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机构:
Univ Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, Italy
Ist Sci San Raffaele, Div Neurosci, I-20127 Milan, ItalyUniv Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, Italy
机构:
PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033
KALES, A
CALDWELL, AB
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PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033
CALDWELL, AB
CADIEUX, RJ
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PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033
CADIEUX, RJ
VELABUENO, A
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PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033
VELABUENO, A
RUCH, LG
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h-index: 0
机构:
PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033
RUCH, LG
MAYES, SD
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h-index: 0
机构:
PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033
机构:
Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
Vet Affairs San Diego Healthcare Syst, Res Serv, San Diego, CA USAUniv Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
Ayalon, Liat
Ancoli-Israel, Sonia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USAUniv Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
Ancoli-Israel, Sonia
Drummond, Sean P. A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
Vet Affairs San Diego Healthcare Syst, Psychol Serv, San Diego, CA USAUniv Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
机构:
Ist Sci San Raffaele, Div Neurosci, I-20127 Milan, Italy
Univ Vita Salute San Raffaele, CRESA, I-20127 Milan, Italy
Univ Vita Salute San Raffaele, Ctr Cognit Neurosci, I-20127 Milan, Italy
Univ Vita Salute San Raffaele, CERMAC, I-20127 Milan, ItalyUniv Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, Italy
Canessa, Nicola
Castronovo, Vincenza
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, ItalyUniv Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, Italy
Castronovo, Vincenza
Cappa, Stefano F.
论文数: 0引用数: 0
h-index: 0
机构:
Ist Sci San Raffaele, Div Neurosci, I-20127 Milan, Italy
Univ Vita Salute San Raffaele, CRESA, I-20127 Milan, Italy
Univ Vita Salute San Raffaele, Ctr Cognit Neurosci, I-20127 Milan, Italy
Univ Vita Salute San Raffaele, CERMAC, I-20127 Milan, ItalyUniv Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, Italy
Cappa, Stefano F.
Aloia, Mark S.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Jewish Med & Res Ctr, Dept Med, Denver, CO USAUniv Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, Italy
Aloia, Mark S.
Marelli, Sara
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, ItalyUniv Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, Italy
Marelli, Sara
Falini, Andrea
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vita Salute San Raffaele, Neuroradiol Unit, I-20127 Milan, Italy
Univ Vita Salute San Raffaele, CERMAC, I-20127 Milan, ItalyUniv Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, Italy
Falini, Andrea
Alemanno, Federica
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h-index: 0
机构:
Ist Sci San Raffaele, Div Neurosci, I-20127 Milan, Italy
Univ Vita Salute San Raffaele, Ctr Cognit Neurosci, I-20127 Milan, Italy
Univ Vita Salute San Raffaele, CERMAC, I-20127 Milan, ItalyUniv Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, Italy
Alemanno, Federica
Ferini-Strambi, Luigi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, Italy
Ist Sci San Raffaele, Div Neurosci, I-20127 Milan, ItalyUniv Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, Italy
机构:
PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033
KALES, A
CALDWELL, AB
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h-index: 0
机构:
PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033
CALDWELL, AB
CADIEUX, RJ
论文数: 0引用数: 0
h-index: 0
机构:
PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033
CADIEUX, RJ
VELABUENO, A
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h-index: 0
机构:
PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033
VELABUENO, A
RUCH, LG
论文数: 0引用数: 0
h-index: 0
机构:
PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033
RUCH, LG
MAYES, SD
论文数: 0引用数: 0
h-index: 0
机构:
PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PSYCHIAT,HERSHEY,PA 17033