Sleep Apnea and the Risk of Dementia: A Population-Based 5-Year Follow-Up Study in Taiwan

被引:110
作者
Chang, Wei-Pin [1 ]
Liu, Mu-En [2 ]
Chang, Wei-Chiao [3 ]
Yang, Albert C. [4 ,5 ]
Ku, Yan-Chiou [6 ]
Pai, Jei-Tsung [1 ]
Huang, Hsiao-Ling [1 ]
Tsai, Shih-Jen [4 ,5 ]
机构
[1] Yuanpei Univ, Dept Healthcare Management, Hsinchu, Taiwan
[2] Kaohsiung Vet Gen Hosp, Dept Psychiat, Kaohsiung, Taiwan
[3] Taipei Med Univ, Sch Pharm, Dept Clin Pharm, Taipei, Taiwan
[4] Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan
[5] Natl Yang Ming Univ, Div Psychiat, Sch Med, Taipei 112, Taiwan
[6] Kaohsiung Vet Gen Hosp, Dept Nursing, Kaohsiung, Taiwan
来源
PLOS ONE | 2013年 / 8卷 / 10期
关键词
INTERMITTENT HYPOXIA; ALZHEIMERS-DISEASE; WOMEN; MEMORY; ASSOCIATION; PERFORMANCE; CORTEX; RAT; AGE;
D O I
10.1371/journal.pone.0078655
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: Sleep apnea (SA) has been associated with cognitive impairment. However, no data regarding the risk of dementia in patients with SA has been reported in the general population. This retrospective matched-control cohort study was designed to estimate and compare the risk of dementia in SA and non-SA patients among persons aged 40 and above over a 5-year period follow-up. Methods: We conducted a nationwide 5-year population-based study using data retrieved from the Longitudinal Health Insurance Database 2005 (LHID2005) in Taiwan. The study cohort comprised 1414 patients with SA aged 40 years who had at least 1 inpatient service claim or 1 ambulatory care claim. The comparison cohort comprised 7070 randomly selected patients who were matched with the study group according to sex, age, and index year. We performed Cox proportional-hazards regressions to compute the 5-year dementia-free survival rates after adjusting for potentially confounding factors. Results: The SA patients in this study had a 1.70-times greater risk of developing dementia within 5 years of diagnosis compared to non-SA age-and sex-matched patients, after adjusting for other risk factors (95% confidence interval (CI) = 1.26-2.31; P < .01). For the gender-dependent effect, only females with SA were more likely to develop dementia (adjust HR: 2.38, 95% CI = 1.51-3.74; P < .001). For the age-dependent effect of different genders, males with SA aged 50-59 years had a 6.08 times greater risk for developing dementia (95% CI = 1.96-18.90), and females with SA aged >= 70 years had a 3.20 times greater risk of developing dementia (95% CI = 1.71-6.00). For the time-dependent effect, dementia may be most likely to occur in the first 2.5 years of follow-up (adjusted HR: 2.04, 95% CI = 1.35-3.07). Conclusions: SA may be a gender-dependent, age-dependent, and time-dependent risk factor for dementia.
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页数:8
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