Anti-steatotic and anti-inflammatory roles of syringic acid in high-fat diet-induced obese mice

被引:108
作者
Ham, Ju Ri [1 ]
Lee, Hae-In [2 ]
Choi, Ra-Yeong [1 ]
Sim, Mi-Ok [3 ]
Seo, Kwon-Il [4 ]
Lee, Mi-Kyung [1 ,5 ]
机构
[1] Sunchon Natl Univ, Dept Food & Nutr, Sunchon 57922, South Korea
[2] Mokpo Marin Food Ind Res Ctr, Mokpo 58621, South Korea
[3] Jeollanamdo Dev Inst Korean Tradit Med, Jangheung 59338, South Korea
[4] Dong A Univ, Dept Biotechnol, Busan 49315, South Korea
[5] Suncheon Res Ctr Nat Med, Sunchon 57922, South Korea
关键词
LEPTIN-DEFICIENT MICE; LIVER-DISEASE; PPAR-GAMMA; CHOLESTEROL-SYNTHESIS; LIPID-ACCUMULATION; HEPATIC EXPRESSION; INSULIN-RESISTANCE; GENE-EXPRESSION; VISCERAL FAT; RECEPTOR;
D O I
10.1039/c5fo01329a
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This study examined the effects of syringic acid (SA) on obese diet-induced hepatic dysfunction. Mice were fed high-fat diet (HFD) with or without SA (0.05%, wt/wt) for 16 weeks. SA reduced the body weight, visceral fat mass, serum levels of leptin, TNF alpha, IFN gamma, IL-6 and MCP-1, insulin resistance, hepatic lipid content, droplets and early fibrosis, whereas it elevated the circulation of adiponectin. SA down-regulated lipogenic genes (Cidea, Ppar gamma, Srebp-1c, Srebp-2, Hmgcr, Fasn) and inflammatory genes (Tlr4, Myd88, NF-kappa B, Tnf alpha, Il6), whereas it up-regulated fatty acid oxidation genes (Ppar alpha, Acsl, Cpt1, Cpt2) in the liver. SA also decreased hepatic lipogenic enzyme activities and elevated fatty acid oxidation enzyme activities relative to the HFD group. These findings suggested that dietary SA possesses anti-obesity, anti-inflammatory and anti-steatotic effects via the regulation of lipid metabolic and inflammatory genes. SA is likely to be a new natural therapeutic agent for obesity or non-alcoholic liver disease.
引用
收藏
页码:689 / 697
页数:9
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