Use of aromatic amino acid residues to restrict the dynamics in the hydrophobic core of a designed helix-loop-helix dimer

被引：29
作者：
Dolphin, GT
Brive, L
Johansson, G
Baltzer, L
机构：
[1] GOTHENBURG UNIV,DEPT ORGAN CHEM,S-41296 GOTHENBURG,SWEDEN
[2] UNIV UPPSALA,CTR BIOMED,DEPT BIOCHEM,S-75123 UPPSALA,SWEDEN
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1996年 / 118卷 / 45期
关键词：
D O I：
10.1021/ja960534t
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
[No abstract available]
引用
收藏
页码：11297 / 11298
页数：2
相关论文
共 11 条
[1]   PROTEIN DESIGN - A HIERARCHICAL APPROACH [J].
BRYSON, JW ;
BETZ, SF ;
LU, HS ;
SUICH, DJ ;
ZHOU, HXX ;
ONEIL, KT ;
DEGRADO, WF .
SCIENCE, 1995, 270 (5238) :935-941
[2]  
DILL KA, 1995, PROTEIN SCI, V4, P561
[3]   METAL-ION DEPENDENT MODULATION OF THE DYNAMICS OF A DESIGNED PROTEIN [J].
HANDEL, TM ;
WILLIAMS, SA ;
DEGRADO, WF .
SCIENCE, 1993, 261 (5123) :879-885
[4]   DENOVO DESIGN, EXPRESSION, AND CHARACTERIZATION OF FELIX - A 4-HELIX BUNDLE PROTEIN OF NATIVE-LIKE SEQUENCE [J].
HECHT, MH ;
RICHARDSON, JS ;
RICHARDSON, DC ;
OGDEN, RC .
SCIENCE, 1990, 249 (4971) :884-891
[5]  
HO PS, 1987, J AM CHEM SOC, V109, P6751
[6]   PROTEIN DESIGN BY BINARY PATTERNING OF POLAR AND NONPOLAR AMINO-ACIDS [J].
KAMTEKAR, S ;
SCHIFFER, JM ;
XIONG, HY ;
BABIK, JM ;
HECHT, MH .
SCIENCE, 1993, 262 (5140) :1680-1685
[7]   SYNTHESIS AND BIOPHYSICAL CHARACTERIZATION OF ENGINEERED TOPOGRAPHIC IMMUNOGENIC DETERMINANTS WITH ALPHA-ALPHA-TOPOLOGY [J].
KAUMAYA, PTP ;
BERNDT, KD ;
HEIDORN, DB ;
TREWHELLA, J ;
KEZDY, FJ ;
GOLDBERG, E .
BIOCHEMISTRY, 1990, 29 (01) :13-23
[8]   A CHEMICAL APPROACH TO PROTEIN DESIGN - TEMPLATE-ASSEMBLED SYNTHETIC PROTEINS (TASP) [J].
MUTTER, M ;
VUILLEUMIER, S .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1989, 28 (05) :535-554
[9]   DESIGN, SYNTHESIS AND SOLUTION STRUCTURE OF A HELIX-LOOP-HELIX DIMER - A TEMPLATE FOR THE RATIONAL DESIGN OF CATALYTICALLY ACTIVE POLYPEPTIDES [J].
OLOFSSON, S ;
JOHANSSON, G ;
BALTZER, L .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1995, (11) :2047-2056
[10]   H-1, N-15, C-13 AND (CO)-C-13 ASSIGNMENTS OF HUMAN INTERLEUKIN-4 USING 3-DIMENSIONAL DOUBLE-RESONANCE AND TRIPLE-RESONANCE HETERONUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY [J].
POWERS, R ;
GARRETT, DS ;
MARCH, CJ ;
FRIEDEN, EA ;
GRONENBORN, AM ;
CLORE, GM .
BIOCHEMISTRY, 1992, 31 (17) :4334-4346
12