B-cell development and antigen receptor signalling

被引：9

作者：

Turner, M ^{[1
]}

机构：

[1] Babraham Inst, Lab Lymphocyte Signalling & Dev, Mol Immunol Programme, Cambridge CB2 4AT, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2002年 / 30卷

关键词：

calcium; knockout mice; lymphocyte activation;

D O I：

10.1042/bst0300812

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

B-cell development and function requires the products of the Vav family of genes. Vav proteins act as key components of the antigen receptor signal transduction machinery by integration of signals that control the cell cycle, differentiation and apoptosis. At the molecular level, Vav proteins regulate small-molecular-mass GTPases, phosphoinositide 3-kinase, TEC family tyrosine kinases and intracellular calcium flux.

引用

页码：812 / 815

页数：4

共 30 条

[1]

Bachmann MF, 1999, J IMMUNOL, V163, P137

[2] Nuclear association of tyrosine-phosphorylated Vav to phospholipase C-γ1 and phosphoinositide 3-kinase during granulocytic differentiation of HL-60 cells [J].

Bertagnolo, V ;

Marchisio, M ;

Volinia, S ;

Caramelli, E ;

Capitani, S .

FEBS LETTERS, 1998, 441 (03) :480-484

[3] LYMPHOCYTE-B RECEPTORS AND POLYPHOSPHOINOSITIDE DEGRADATION [J].

BIJSTERBOSCH, MK ;

MEADE, CJ ;

TURNER, GA ;

KLAUS, GGB .

CELL, 1985, 41 (03) :999-1006

[4] Rac GTPase interacts specifically with phosphatidylinositol 3-kinase [J].

Bokoch, GM ;

Vlahos, CJ ;

Wang, Y ;

Knaus, UG ;

TraynorKaplan, AE .

BIOCHEMICAL JOURNAL, 1996, 315 :775-779

[5] Vav proteins, adaptors and cell signaling [J].

Bustelo, XR .

ONCOGENE, 2001, 20 (44) :6372-6381

[6] Vav and the B cell signalosome [J].

DeFranco, AL .

NATURE IMMUNOLOGY, 2001, 2 (06) :482-484

[7] Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation [J].

Doody, GM ;

Bell, SE ;

Vigorito, E ;

Clayton, E ;

McAdam, S ;

Tooze, R ;

Fernandes, C ;

Lee, IJ ;

Turner, M .

NATURE IMMUNOLOGY, 2001, 2 (06) :542-547

[8] Xid-like phenotypes:: A B cell signalosome takes shape [J].

Fruman, DA ;

Satterthwaite, AB ;

Witte, ON .

IMMUNITY, 2000, 13 (01) :1-3

[9] Vav is required for cyclin D2 induction and proliferation of mouse B lymphocytes activated via the antigen receptor [J].

Glassford, J ;

Holman, M ;

Banerji, L ;

Clayton, E ;

Klaus, GGB ;

Turner, M ;

Lam, EWF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (44) :41040-41048

[10] Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response [J].

Guinamard, R ;

Okigaki, M ;

Schlessinger, J ;

Ravetch, JV .

NATURE IMMUNOLOGY, 2000, 1 (01) :31-36

← 1 2 3 →