Fluorinative ring-opening of cyclopropanes by hypervalent iodine reagents. An efficient method for 1,3-oxyfluorination and 1,3-difluorination

被引：87

作者：

Ilchenko, Nadia O. ^{[1
]}

Hedberg, Martin ^{[1
]}

Szabo, Kalman J. ^{[1
]}

机构：

[1] Stockholm Univ, Dept Organ Chem, Arrhenius Lab, SE-10691 Stockholm, Sweden

来源：

CHEMICAL SCIENCE | 2017年 / 8卷 / 02期

基金：

瑞典研究理事会;

关键词：

TRIFLUOROMETHYLATION; AMINOFLUORINATION; CARBOFLUORINATION; OXYFLUORINATION; DERIVATIVES; CHEMISTRY; ALKENES; ARENES; MILD;

D O I：

10.1039/c6sc03471c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new method is presented for 1,3-difluorination and 1,3-oxyfluorination reactions. The process is based on iodonium mediated opening of 1,1-disubstituted cyclopropanes. The reaction proceeds with high chemo and regioselectivity under mild reaction conditions typically at room temperature in a couple of hours. The reaction probably occurs via electrophilic ring-opening of cyclopropanes.

引用

页码：1056 / 1061

页数：6

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