Fluorinative ring-opening of cyclopropanes by hypervalent iodine reagents. An efficient method for 1,3-oxyfluorination and 1,3-difluorination

被引：86
作者：
Ilchenko, Nadia O. [1 ]
Hedberg, Martin [1 ]
Szabo, Kalman J. [1 ]
机构：
[1] Stockholm Univ, Dept Organ Chem, Arrhenius Lab, SE-10691 Stockholm, Sweden
来源：
CHEMICAL SCIENCE | 2017年 / 8卷 / 02期
基金：
瑞典研究理事会;
关键词：
TRIFLUOROMETHYLATION; AMINOFLUORINATION; CARBOFLUORINATION; OXYFLUORINATION; DERIVATIVES; CHEMISTRY; ALKENES; ARENES; MILD;
D O I：
10.1039/c6sc03471c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new method is presented for 1,3-difluorination and 1,3-oxyfluorination reactions. The process is based on iodonium mediated opening of 1,1-disubstituted cyclopropanes. The reaction proceeds with high chemo and regioselectivity under mild reaction conditions typically at room temperature in a couple of hours. The reaction probably occurs via electrophilic ring-opening of cyclopropanes.
引用
收藏
页码：1056 / 1061
页数：6
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