Dysfunction of the Glymphatic System Might Be Related to Iron Deposition in the Normal Aging Brain

被引：53

作者：

Zhou, Wei ^{[1
]}

Shen, Bo ^{[1
]}

Shen, Wei-qiang ^{[1
]}

Chen, Hao ^{[1
]}

Zheng, Yi-feng ^{[1
]}

Fei, Jing-jing ^{[2
]}

机构：

[1] Zhejiang Univ, Huzhou Univ, Huzhou Cent Hosp,Affiliated Cent Hosp, Affiliated Huzhou Hosp,Sch Med,Dept Radiol, Huzhou, Peoples R China

[2] Zhejiang Univ, Huzhou Univ, Huzhou Cent Hosp,Affiliated Cent Hosp, Affiliated Huzhou Hosp,Sch Med,Dept Internal Med, Huzhou, Peoples R China

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2020年 / 12卷

关键词：

glymphatic system; iron deposition; aging; brain; MRI; ALZHEIMERS-DISEASE; CLEARANCE;

D O I：

10.3389/fnagi.2020.559603

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objective: The study aims to detect the potential relationship between iron deposition and the function of the glymphatic system in the normal aging brain. Methods: We recruited 213 healthy participants. We evaluated the function of the glymphatic system using the index for diffusivity along the perivascular space (ALPS-index), assessed iron deposition on quantitative susceptibility mapping (QSM), and analyzed their relationship. Results: The mean age of participants was 60.1 +/- 7.3, and 107 (50.2%) were female. The mean ALPS-index was 1.4 +/- 0.2. The QSM values of the caudate nucleus, putamen, globus pallidus, thalamus, red nucleus, substantia nigra, and dentate nucleus were all related to the ALPS-index (all P < 0.001). Conclusions: The main finding of the current study is that the regional brain iron deposition was related to the function of the glymphatic system. Advances in knowledge: We first evaluated the relationship between deposition of brain iron and the dysfunction of the glymphatic system.

引用

页数：6

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