Molecular Basis for Cancer Chemoprevention by Green Tea Polyphenol EGCG

被引：62
作者：
Tachibana, Hirofumi [1 ,2 ]
机构：
[1] Kyushu Univ, Fac Agr, Dept Biosci & Biotechnol, Higashi Ku, Fukuoka 8128581, Japan
[2] Kyushu Univ, Bioarchitecture Ctr, Fukuoka 8128581, Japan
来源：
FOOD FACTORS FOR HEALTH PROMOTION | 2009年 / 61卷
关键词：
GROWTH-FACTOR RECEPTOR; KDA LAMININ RECEPTOR; SIGNALING PATHWAY; DIRECT INHIBITION; (-)-EPIGALLOCATECHIN-3-GALLATE; EXPRESSION; CATECHINS; EPIGALLOCATECHIN-3-O-GALLATE; PHOSPHORYLATION; PROTEIN;
D O I：
10.1159/000212748
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
For the past two decades, many researchers have been investigating the potential cancer-preventive and therapeutic effects of green tea. (-)-Epigallocatechin-3-O-gallate (EGCG) has been shown to be the most active and major polyphenolic compound from green tea. The mechanisms of action of EGCG have been extensively investigated. However, the mechanisms for the cancer-preventive activity of EGCG are not completely characterized and many features remain to be elucidated. Recently, we have identified the 67-kDa laminin receptor (67LR) as a cell surface EGCG receptor that confers EGCG responsiveness to many cancer cells at physiological concentrations. This article reviews some of the reported mechanisms and possible targets for the action of EGCG. We especially focus on the current understanding of the signaling pathway for physiologically relevant EGCG through the 67LR for cancer prevention. Our data shed new light on the molecular basis for the cancer-preventive activity of EGCG in vivo and helps in the design of new strategies to prevent cancer. Copyright (C) 2009 S. Karger AG, Basel
引用
收藏
页码：156 / 169
页数：14
相关论文
共 28 条
[1]   Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: A preliminary report from a one-year proof-of-principle study [J].
Bettuzzi, S ;
Brausi, M ;
Rizzi, F ;
Castagnetti, G ;
Peracchia, G ;
Corti, A .
CANCER RESEARCH, 2006, 66 (02) :1234-1240
[2]   Mechanisms of inhibition of the Ras-MAP kinase signaling pathway in 30.7b Ras 12 cells by tea polyphenols (-)-epigallocatechin-3-gallate and theaflavin-3,3′-digallate [J].
Chung, JY ;
Park, JO ;
Phyu, H ;
Dong, ZG ;
Yang, CS .
FASEB JOURNAL, 2001, 15 (09) :2022-+
[3]   Lysosomal trafficking of β-catenin induced by the tea polyphenol epigallocatechin-3-gallate [J].
Dashwood, WM ;
Carter, O ;
Al-Fageeh, M ;
Li, QJ ;
Dashwood, RH .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2005, 591 (1-2) :161-172
[4]   The intermediate filament protein vimentin is a new target for epigallocatechin gallate [J].
Ermakova, S ;
Choi, BY ;
Choi, HS ;
Kang, BS ;
Bode, AM ;
Dong, ZG .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (17) :16882-16890
[5]   A lipid raft-associated 67 kDa laminin receptor mediates suppressive effect of epigallocatechin-3-O-gallate on FcεRI expression [J].
Fujimura, Y ;
Yamada, K ;
Tachibana, H .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 336 (02) :674-681
[6]   Lipid raft-associated catechin suppresses the FcεRI expression by inhibiting phosphorylation of the extracellular signal-regulated kinase1/2 [J].
Fujimura, Y ;
Tachibana, H ;
Yamada, K .
FEBS LETTERS, 2004, 556 (1-3) :204-210
[7]   The 67 kDa laminin receptor as a primary determinant of anti-allergic effects of O-methylated EGCG [J].
Fujimura, Yoshinori ;
Umeda, Daisuke ;
Yano, Satomi ;
Maeda-Yamamoto, Mari ;
Yamada, Koji ;
Tachibana, Hirofumi .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 364 (01) :79-85
[8]  
HARTSHORNE DJ, 2004, J BIOL CHEM, V273, P5542
[9]   Tea catechins and polyphenols: Health effects, metabolism, and antioxidant functions [J].
Higdon, JV ;
Frei, B .
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2003, 43 (01) :89-143
[10]  
Hong J, 2002, CANCER RES, V62, P7241
123