Switch peptides in statu nascendi:: Induction of conformational transitions relevant to degenerative diseases

被引：149
作者：
Mutter, M [1 ]
Chandravarkar, A [1 ]
Boyat, C [1 ]
Lopez, J [1 ]
Dos Santos, S [1 ]
Mandal, B [1 ]
Mimna, R [1 ]
Murat, K [1 ]
Patiny, L [1 ]
Saucède, L [1 ]
Tuchscherer, G [1 ]
机构：
[1] Swiss Fed Inst Technol, EPFL BCH, Inst Chem Sci & Engn, CH-1015 Lausanne, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 32期
关键词：
Alzheimer's disease; circular dichroism; protein folding; protein structures; switch peptides;
D O I：
10.1002/anie.200454045
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel concept for triggering conformational transitions, and thus changes in structure and function, in peptides with a switching element S provides intriguing perspectives for studying molecular processes (see scheme) that play a key role, for example, in early events of Alzheimer's disease.
引用
收藏
页码：4172 / 4178
页数：7
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