Evaluation of the bioavailability of hydrocortisone when prepared as solid dispersion

被引:33
作者
Altamimi, Mohammad A. [1 ,2 ]
Elzayat, Ehab M. [1 ]
Qamar, Wajhul [2 ,3 ]
Alshehri, Sultan M. [1 ]
Sherif, Abdelrahman Y. [1 ]
Haq, Nazrul [1 ]
Shakeel, Faiyaz [1 ]
机构
[1] King Saud Univ, Coll Pharm, Dept Pharmaceut, Riyadh, Saudi Arabia
[2] King Saud Univ, Coll Pharm, Cent Lab, Riyadh, Saudi Arabia
[3] King Saud Univ, Coll Pharm, Dept Pharmacol & Toxicol, Riyadh, Saudi Arabia
关键词
Hydrocortisone; Solid dispersion; Spray drying; Low potency; Bioavailability; PEG; 4000; Kolliphor (R) P 407; SUPERCRITICAL CARBON-DIOXIDE; HOT-MELT EXTRUSION; DISSOLUTION RATE; PHARMACEUTICAL APPLICATIONS; PHYSICAL STABILITY; ORAL ABSORPTION; ANTI-SOLVENT; PEG; 6000; DRUG; ENHANCEMENT;
D O I
10.1016/j.jsps.2019.03.004
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This study was conducted to formulate, characterize, and investigate the bioavailability of hydrocortisone (HCT) when prepared as solid dispersions. no - was mixed in an organic solvent with polyethylene glycol 4000 (PEG 4000) and Kolliphor (R) P 407. Spray drying technique was employed to form a solid dispersion formulation at a specific ratio. Physical and chemical characterization of the formed particles were achieved using differential scanning calorimetry, scanning electron microscopy, Fourier transform infrared spectroscopy, and powder X-ray diffractometry. Furthermore, comparative in vitro and in vivo studies were conducted between the formulated particles against neat HCT. The formulated solid dispersion showed elongated particles with leaf-like structure. Formation of new chemical bonds in the formed particle was suggested due to the change in the vibrational wave numbers and the significant improvement in the bioavailability of the dispersed particles proved the importance of this technique. (C) 2019 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
引用
收藏
页码:629 / 636
页数:8
相关论文
共 53 条
[1]   Hydrocortisone nanosuspensions for ophthalmic delivery: A comparative study between microfluidic nanoprecipitation and wet milling [J].
Ali, Hany S. M. ;
York, Peter ;
Ali, Ahmed M. A. ;
Blagden, Nicholas .
JOURNAL OF CONTROLLED RELEASE, 2011, 149 (02) :175-181
[2]   Solubility of Budesonide, Hydrocortisone, and Prednisolone in Ethanol plus Water Mixtures at 298.2 K [J].
Ali, Hany S. M. ;
York, Peter ;
Blagden, Nicholas ;
Soltanpour, Shahla ;
Acree, William E., Jr. ;
Jouyban, Abolghasem .
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2010, 55 (01) :578-582
[3]   Stochiometrically governed molecular interactions in drug: Poloxamer solid dispersions [J].
Ali, W. ;
Williams, A. C. ;
Rawlinson, C. F. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2010, 391 (1-2) :162-168
[4]   Utilizing spray drying technique to improve oral bioavailability of apigenin [J].
Altamimi, Mohammad A. ;
Elzayat, Ehab M. ;
Alshehri, Sultan M. ;
Mohsin, Kazi ;
Ibrahim, Mohamed A. ;
Al Meanazel, Osaid T. ;
Shakeel, Faiyaz ;
Alanazi, Fars K. ;
Alsarra, Ibrahim A. .
ADVANCED POWDER TECHNOLOGY, 2018, 29 (07) :1676-1684
[5]   Investigation of the in vitro performance difference of drug-Soluplus® and drug-PEG 6000 dispersions when prepared using spray drying or lyophilization [J].
Altamimi, Mohammad A. ;
Neau, Steven H. .
SAUDI PHARMACEUTICAL JOURNAL, 2017, 25 (03) :419-439
[6]   Use of the Flory-Huggins theory to predict the solubility of nifedipine and sulfamethoxazole in the triblock, graft copolymer Soluplus [J].
Altamimi, Mohammad A. ;
Neau, Steven H. .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2016, 42 (03) :446-455
[7]   A Classification System to Assess the Crystallization Tendency of Organic Molecules from Undercooled Melts [J].
Baird, Jared A. ;
Van Eerdenbrugh, Bernard ;
Taylor, Lynne S. .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2010, 99 (09) :3787-3806
[8]   Surface characterization by FTIR-ATR spectroscopy of polyethersulfone membranes-unmodified, modified and protein fouled [J].
Belfer, S ;
Fainchtain, R ;
Purinson, Y ;
Kedem, O .
JOURNAL OF MEMBRANE SCIENCE, 2000, 172 (1-2) :113-124
[9]   Enhancement of dissolution of glyburide by solid dispersion and lyophilization techniques [J].
Betageri, GV ;
Makarla, KR .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1995, 126 (1-2) :155-160
[10]   Enhancement of dissolution rate of gliclazide using solid dispersions with polyethylene glycol 6000 [J].
Biswal, S. ;
Sahoo, J. ;
Murthy, P. N. ;
Giradkar, R. P. ;
Avari, J. G. .
AAPS PHARMSCITECH, 2008, 9 (02) :563-570