Synthesis of potential buprenorphine intermediates by selective microbial N- and O-demethylation

被引：7
|
作者：
Abel, AM
Carnell, AJ [1 ]
Davis, JA
Paylor, M
机构：
[1] Univ Liverpool, Robert Robinson Labs, Dept Chem, Liverpool L69 7ZD, Merseyside, England
[2] Reckitt Benckiser, Kingston Upon Hull HU8 7DS, N Humberside, England
来源：
BIOTECHNOLOGY LETTERS | 2002年 / 24卷 / 15期
关键词：
buprenorphine; Cunninghamella; demethylation;
D O I：
10.1023/A:1016218211300
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A group of filamentous fungi from the genus Cunninghamella have been identified as potential biocatalysts in the generation of potential buprenorphine intermediates. A simple batch fermentation procedure results in the formation of dealkylated alkaloid compounds that are readily available for analysis and further chemical modification.
引用
收藏
页码：1291 / 1294
页数：4
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