Synthesis of potential buprenorphine intermediates by selective microbial N- and O-demethylation

被引：7

作者：

Abel, AM

Carnell, AJ ^{[1
]}

Davis, JA

Paylor, M

机构：

[1] Univ Liverpool, Robert Robinson Labs, Dept Chem, Liverpool L69 7ZD, Merseyside, England

[2] Reckitt Benckiser, Kingston Upon Hull HU8 7DS, N Humberside, England

来源：

BIOTECHNOLOGY LETTERS | 2002年 / 24卷 / 15期

关键词：

buprenorphine; Cunninghamella; demethylation;

D O I：

10.1023/A:1016218211300

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A group of filamentous fungi from the genus Cunninghamella have been identified as potential biocatalysts in the generation of potential buprenorphine intermediates. A simple batch fermentation procedure results in the formation of dealkylated alkaloid compounds that are readily available for analysis and further chemical modification.

引用

页码：1291 / 1294

页数：4

共 5 条

[1] N-DEMETHYLATION OF LERGOTRILE BY STREPTOMYCES-PLATENSIS [J].