Exosomal circRNAs: Sorting Mechanisms, Roles and Clinical Applications in Tumors

被引：20
|
作者：
Xu, Yanhua [1 ,2 ,3 ]
Kong, Shan [1 ,2 ,3 ]
Qin, Shiyi [1 ,2 ,3 ]
Shen, Xianjuan [1 ]
Ju, Shaoqing [1 ]
机构：
[1] Nantong Univ, Affiliated Hosp, Dept Lab Med, Nantong, Peoples R China
[2] Nantong Univ, Affiliated Hosp, Res Ctr Clin Med, Nantong, Peoples R China
[3] Nantong Univ, Sch Med, Nantong, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2020年 / 8卷
基金：
中国国家自然科学基金;
关键词：
exosomes; circRNAs; biomarkers; drug resistance; therapeutic targets; exosomal circRNAs; CIRCULAR RNA; COLORECTAL-CANCER; HEPATOCELLULAR-CARCINOMA; EXTRACELLULAR VESICLES; DIAGNOSTIC BIOMARKERS; TRANSFERRIN RECEPTOR; MICRORNA BIOGENESIS; MEDIATED TRANSFER; MESSENGER-RNAS; PROTEINS;
D O I：
10.3389/fcell.2020.581558
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Exosomes are a group of nano-sized membrane vesicles and are important mediators of intercellular communication, particularly in tumor microenvironment. Recently, researchers have found that circular RNAs (circRNAs), with the great research significance, are enriched and stable in exosomes. In this review, we summarize the research significance of exosomal circRNAs, sorting mechanisms and their functioning mechanisms in tumor progression. Their clinical applications as clinical tumor biomarkers and as therapeutic targets in inhibiting tumor metastasis, anti-cancer immunity response and drug resistance have been widely discussed.
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页数：14
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