Lysosomal involvement in cell death and cancer

被引：317

作者：

Kirkegaard, Thomas ^{[1
]}

Jaattela, Marja ^{[1
]}

机构：

[1] Danish Canc Soc, Dept Apoptosis, Inst Canc Biol, Copenhagen, Denmark

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2009年 / 1793卷 / 04期

关键词：

Lysosomes; Cathepsins; Cancer; Apoptosis; Transformation; Cell death; NECROSIS-FACTOR-ALPHA; CYTOCHROME-C RELEASE; CATHEPSIN-B; HEAT-SHOCK-PROTEIN-70; HSP70; INDUCED APOPTOSIS; MEMBRANE PERMEABILIZATION; ACIDIC SPHINGOMYELINASE; CYSTEINE CATHEPSINS; DEPENDENT APOPTOSIS; CASPASE ACTIVATION;

D O I：

10.1016/j.bbamcr.2008.09.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lysosomes, with their arsenal of degradative enzymes are increasingly becoming an area of interest in the field of oncology. The changes induced in this compartment upon transformation are numerous and whereas most are viewed as pro-oncogenic the same processes also render cancer cells susceptible to lysosomal death pathways. This review will provide an overview of the pro- and anti-oncogenic potential of this compartment and how these might be exploited for cancer therapy, with special focus on lysosomal death pathways. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：746 / 754

页数：9

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