Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy

被引：116
作者：
Mazarati, Andrey M. [1 ]
Shin, Don [1 ]
Kwon, Young Se [1 ,4 ]
Bragin, Anatol [2 ]
Pineda, Eduardo [1 ]
Tio, Delia [3 ]
Taylor, Anna N. [3 ]
Sankar, Raman [1 ,2 ]
机构：
[1] Univ Calif Los Angeles, Dept Pediat, Div Neurol, David Geffen Sch Med, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA
[4] Inha Univ, Dept Pediat, Coll Med, Inchon, South Korea
来源：
NEUROBIOLOGY OF DISEASE | 2009年 / 34卷 / 03期
基金：
美国国家卫生研究院;
关键词：
Epilepsy; Depression; Co-morbidity; Hypothalamo-pituitary-adrenocortical axis; Chronic stress; STATUS EPILEPTICUS; MAJOR DEPRESSION; STRESS; RAT; EPILEPTOGENESIS; MODEL; SEROTONIN; RESPONSES; SEIZURES; HORMONE;
D O I：
10.1016/j.nbd.2009.02.018
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Depression is frequently reported in epilepsy patients; however, mechanisms of co-morbidity between epilepsy and depression are poorly understood. An important mechanism of depression is disinhibition within the hypothalamo-pituitary-adrenocortical (HPA) axis. We examined the functional state of the HPA axis in a rat model of co-morbidity between temporal lobe epilepsy and depression. Epilepsy was accompanied by the interictal elevation of plasma corticosterone, and by the positively combined dexamethasone/corticotropin releasing hormone test. The extent of the HPA hyperactivity was independent of recurrent seizures, but positively correlated with the severity of depressive behavior. We suggest that the observed hyperactivity of the HPA axis may underlie co-morbidity between epilepsy and depression. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：457 / 461
页数：5
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