Effect of gelatin addition on fabrication of magnesium phosphate-based scaffolds prepared by additive manufacturing system

被引：56
作者：
Farag, M. M. [1 ,2 ]
Yun, Hui-suk [1 ]
机构：
[1] Korea Inst Mat Sci, Powder & Ceram Div, Chang Won 641831, South Korea
[2] Natl Res Ctr, Biomat Dept, Cairo 12622, Egypt
来源：
MATERIALS LETTERS | 2014年 / 132卷
关键词：
Gelatin; Magnesium phosphate; Additive manufacturing; Cement reaction; Bone scaffold; COMPOSITE SCAFFOLDS; TISSUE; DESIGN;
D O I：
10.1016/j.matlet.2014.06.055
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
A gelatin/magnesium phosphate (MgP) three-dimensional (3D) porous scaffold for use in bone tissue regeneration was developed through the combination of an additive manufacturing (AM) system and bone cement chemistry. Temperature during 3D manufacturing was carefully studied, due to its importance to sol-gel transition of gelatin. At 25 degrees C, the addition of appropriate gelatin ( < 6 wt%) content to MgP greatly improved the mechanical properties of ceramic scaffolds (compressive strength=16.7 +/- 1.9 MPa) as well as initial cell affinity, and affected drug (lysozyme) release performance. (C) 2014 Published by Elsevier B.V.
引用
收藏
页码：111 / 115
页数：5
相关论文
共 29 条
[1]   Biomimetic composite coating on rapid prototyped scaffolds for bone tissue engineering [J].
Arafat, M. Tarik ;
Lam, Christopher X. F. ;
Ekaputra, Andrew K. ;
Wong, Siew Yee ;
Li, Xu ;
Gibson, Ian .
ACTA BIOMATERIALIA, 2011, 7 (02) :809-820
[2]   Bone tissue engineering using 3D printing [J].
Bose, Susmita ;
Vahabzadeh, Sahar ;
Bandyopadhyay, Amit .
MATERIALS TODAY, 2013, 16 (12) :496-504
[3]   Effect of dilute gelatine on the ultrasonic thermally assisted synthesis of nano hydroxyapatite [J].
Brundavanam, Ravi Krishna ;
Jiang, Zhong-Tao ;
Chapman, Peter ;
Le, Xuan-Thi ;
Mondinos, Nicholas ;
Fawcett, Derek ;
Poinern, Gerrard Eddy Jai .
ULTRASONICS SONOCHEMISTRY, 2011, 18 (03) :697-703
[4]   Functionalization of poly(caprolactone) scaffolds by the surface mineralization for use in bone regeneration [J].
Dorj, Biligzaya ;
Kim, Mi-Kyung ;
Won, Jong-Eun ;
Kim, Hae-Won .
MATERIALS LETTERS, 2011, 65 (23-24) :3559-3562
[5]   Bioceramics of calcium orthophosphates [J].
Dorozhkin, Sergey V. .
BIOMATERIALS, 2010, 31 (07) :1465-1485
[6]  
Grossardt C, 2010, TISSUE ENG PT A, V16, P3687, DOI [10.1089/ten.tea.2010.0281, 10.1089/ten.TEA.2010.0281]
[7]   Porous scaffold design for tissue engineering [J].
Hollister, SJ .
NATURE MATERIALS, 2005, 4 (07) :518-524
[8]  
Hutmacher DW, 2001, J BIOMED MATER RES, V55, P203, DOI 10.1002/1097-4636(200105)55:2<203::AID-JBM1007>3.3.CO
[9]  
2-Z
[10]   Challenges in tissue engineering [J].
Ikada, Yoshito .
JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2006, 3 (10) :589-601
123