MicroRNAs: Biogenesis, function and applications

被引：5
|
作者：
Chua, Jia Hui [1 ]
Armugam, Arunmozhiarasi [1 ]
Jeyaseelan, Kandiah [1 ]
机构：
[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117597, Singapore
来源：
CURRENT OPINION IN MOLECULAR THERAPEUTICS | 2009年 / 11卷 / 02期
关键词：
Antagomir; biomarker; gene silencing; miRNA; siRNA; therapeutic; HUMAN LUNG CANCERS; IN-VIVO; RNA-INTERFERENCE; LET-7; MICRORNA; POSTTRANSCRIPTIONAL REGULATION; CHEMICAL-MODIFICATION; EXPRESSION PATTERNS; CELLULAR MICRORNAS; PROTEIN-SYNTHESIS; MAMMALIAN-CELLS;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
MicroRNAs (miRNAs) belong to the group of non-coding, small RNAs (19 to 21 nucleotide-long oligonucleotides) that are endogenously produced from their own genes. miRNAs interfere with or affect the transcription or translation of other genes, resulting in gene silencing or activation by a process known as RNAi or RNA activation, respectively. The discovery of miRNAs and related small RNAs within the last 10 years has opened up a new field in biology, called RNomics, which investigates differences in RNA populations and offers great potential in correcting the regulation of abnormally expressed and disease-causing genes, as well as in the development of novel therapeutic agents. This review focuses on the developments in miRNAs and their potential therapeutic applications.
引用
收藏
页码：189 / 199
页数：11
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