Characterization of Chondroblastic Osteosarcoma: Gadolinium-Enhanced Versus Diffusion-Weighted MR Imaging

Purpose: To detect differences in magnetic resonance imaging (MRI) between chondroblastic osteosarcoma and the other types of osteosarcomas or chondrosarcomas using gadolinium-enhanced versus diffusion-weighted sequences. Materials and Methods: Contrast-enhanced MRI and diffusion-weighted Imaging (DWI) were performed in five chondroblastic osteosarcoma (CO) cases, 17 other types of osteosarcomas (OS), and 18 chondrosarcomas (CS). DWI was obtained with a single-shot echo-planar imaging (EPI) sequence using a 1.5T MR Imager. The apparent diffusion coefficients (ADCs) of the minimum and maximum values were also obtained. The contrast-enhancement pattern was evaluated and minimum-maximum ADC value of CO was compared with other types of OS and CS. Results: Both CO and CS showed a similar enhancement pattern: both showed septonodular and peripheral rim enhancement. The minimum ADC value of CO (1.24 +/- 0. 10 x 10(-3)mm(2)/sec) was significantly higher than that of other types of OS (0.84 +/- 0.15 x 10(-3)mm(2)/sec) and was significantly lower than that of CS (1.64 +/- 0.20 x 10(-3)mm(2)/sec), In addition, the maximum ADC value of CO (2.28 +/- 0.20 x 10(-3) mm(2)/sec) was significantly higher than that of other types of OS (1.33 +/- 0.26 x 10(-3)mm(2)/sec). Conclusion: DWI appears to be more useful for differentiating between chondroblastic osteosarcoma and chondrosarcoma or other types of osteosarcoma than Gd-enhanced MRI.