Triggering receptor expressed on myeloid cells 2 variants are rare in Parkinson's disease in a Han Chinese cohort

被引：15

作者：

Feng, Shu-jun ^{[1
]}

Nie, Kun ^{[1
]}

Gan, Rong ^{[1
]}

Huang, Jing ^{[1
]}

Zhang, You-wen ^{[1
]}

Wang, Li-min ^{[1
]}

Zhao, Jie-hao ^{[1
]}

Tang, Hong-mei ^{[1
]}

Gao, Liang ^{[1
]}

Zhu, Rui-ming ^{[1
]}

Duan, Zhen-peng ^{[1
]}

Zhang, Yu-hu ^{[1
]}

Wang, Li-juan ^{[1
]}

机构：

[1] Guangdong Acad Med Sci, Guangdong Gen Hosp, Guangdong Neurosci Inst, Dept Neurol, Guangzhou 510080, Guangdong, Peoples R China

来源：

NEUROBIOLOGY OF AGING | 2014年 / 35卷 / 07期

基金：

中国国家自然科学基金;

关键词：

TREM2; Polymorphism; Parkinson's disease; Chinese; Variant;

D O I：

10.1016/j.neurobiolaging.2014.01.142

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Recent studies have reported that a rare nonsynonymous variant rs75932628-T in the TREM2 gene is associated with increased risk of Alzheimer's disease and Parkinson's disease (PD) in Europeandescended populations. However, the association between rare TREM2 mutations and PD risk remains unknown in Chinese population. We directly sequenced exon2 of TREM2 in a cohort of 476 PD patients and 432 healthy controls from a Han Chinese population. Rs75932628-T (p. R47H) was found in 0.2% of PD cases (1/476) but in none of the controls (0/432, p = 1.000), with a minor allele frequency of 0.06% among the 908 subjects. Our findings suggest that variants in exon2 of TREM2 are extremely rare, and it is not a genetic risk factor for PD in the southern Han Chinese population. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：1780.e11 / 1780.e12

页数：2