BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

被引：16

作者：

Dudnik, Alexey ^{[1
]}

Almeida, A. Filipa ^{[15
,20
]}

Andrade, Ricardo ^{[2
]}

Avila, Barbara ^{[3
]}

Banados, Pilar

Barbay, Diane ^{[4
]}

Bassard, Jean-Etienne ^{[5
]}

Benkoulouche, Mounir ^{[4
]}

Bott, Michael ^{[6
]}

Braga, Adelaide ^{[7
,21
]}

Breitel, Dario ^{[12
]}

Brennan, Rex ^{[10
]}

Bulteau, Laurent ^{[2
]}

Chanforan, Celine ^{[8
]}

Costa, Ines ^{[15
,20
]}

Costa, Rafael S. ^{[9
]}

Doostmohammadi, Mahdi ^{[9
,22
]}

Faria, Nuno ^{[7
,21
]}

Feng, Chengyong ^{[17
]}

Fernandes, Armando ^{[9
]}

Ferreira, Patricia ^{[7
,21
]}

Ferro, Roberto ^{[1
]}

Foito, Alexandre ^{[10
]}

Freitag, Sabine ^{[10
]}

Garcia, Goncalo ^{[15
,20
]}

Gaspar, Paula ^{[1
]}

Godinho-Pereira, Joana ^{[15
,20
]}

Hamberger, Bjorn ^{[5
]}

Hartmann, Andras ^{[9
]}

Heider, Harald ^{[4
]}

Jardim, Carolina ^{[15
,20
]}

Julien-Laferriere, Alice ^{[2
]}

Kallscheuer, Nicolai ^{[6
]}

Kerbe, Wolfgang ^{[13
]}

Kuipers, Oscar P. ^{[11
]}

Li, Shanshan ^{[17
]}

Love, Nicola ^{[12
]}

Marchetti-Spaccamela, Alberto ^{[2
]}

Marienhagen, Jan ^{[6
]}

Martin, Cathie ^{[12
]}

Mary, Arnaud ^{[2
]}

Mazurek, Vincent ^{[8
]}

Meinhart, Camillo ^{[13
]}

Sevillano, David Mendez ^{[14
]}

Menezes, Regina ^{[15
,20
]}

Naesby, Michael ^{[4
]}

Norholm, Morten H. H. ^{[1
]}

Okkels, Finn T.

Oliveira, Joana ^{[7
,21
]}

Ottens, Marcel ^{[14
]}

机构：

[1] Tech Univ Denmark, Novo Nordisk Fdn Ctr Biosustainabil, Bldg 220, DK-2800 Lyngby, Denmark

[2] Inst Natl Rech Informat & Automat, 43 Blvd 11 Novembre 1918, F-69622 Villeurbanne, France

[3] Pontificia Univ Catolica Chile, Fac Agron & Ingn Forestal, Av Vicuna Mackenna Ote, Macul 4860, Chile

[4] Evolva, Duggingerstr 23, CH-4053 Reinach, Switzerland

[5] Univ Copenhagen, Dept Plant & Environm Sci, DK-1871 Frederiksberg, Denmark

[6] Forschungszentrum Julich GmbH, Inst Bio & Geowissensch, IBG Biotechnol 1, Wilhelm Johnen Str, D-52428 Julich, Germany

[7] Biotempo, Avepk Edif Spinpk, P-4805017 Guimaraes, Portugal

[8] Chr Hansen Nat Colors AS, Agern Alle 24, DK-2970 Horsholm, Denmark

[9] Univ Lisbon, IDMEC, Inst Super Tecn, P-1049001 Lisbon, Portugal

[10] James Hutton Inst, Invergowrie, Dundee DD2 5DA, Scotland

[11] Univ Groningen, Dept Mol Genet, Groningen Biomol Sci & Biotechnol Inst, Nijenborgh 7, NL-9747 AG Groningen, Netherlands

[12] John Innes Ctr, Norwich Res Pk, Norwich NR4 7UH, Norfolk, England

[13] Biofact KG, Kundmanngasse 39-12, A-1030 Vienna, Austria

[14] Delft Univ Technol, Dept Biotechnol, Maasweg 9, NL-2629 HZ Delft, Netherlands

[15] iBET, Inst Biol Expt & Tecnol, Apartado 12, P-2780901 Oeiras, Portugal

[16] NI Vavilov Res Inst Plant Ind, Fruit Crops Genet Resources Dept, B Morskaya St 42-44, St Petersburg 190000, Russia

[17] Chinese Acad Sci, Inst Bot, 20 Nanxincun, Beijing 100093, Peoples R China

[18] Chr Hansen Holding AS, Boge Alle 10-12, DK-2970 Horsholm, Denmark

[19] Heriot Watt Univ, Inst Mech Proc & Energy Engn, Sch Engn & Phys Sci, Edinburgh, Midlothian, Scotland

[20] Univ Nova Lisboa, Inst Tecnol Quim & Biol Antonio Xavier, P-2780157 Oeiras, Portugal

[21] Univ Minho, Ctr Biol Engn, Campus Gualtar, P-4710057 Braga, Portugal

[22] Univ Edinburgh, Sch Math, Edinburgh EH9 3FD, Midlothian, Scotland

[23] Ctr Wiskunde & Informat, Sci Pk 123, NL-1098 XG Amsterdam, Netherlands

来源：

PHYTOCHEMISTRY REVIEWS | 2018年 / 17卷 / 02期

关键词：

Berries; Bioprospecting; Microbial cell factories; Polyphenols; Sustainable production; DEPENDENT GENE-EXPRESSION; PLANT FLAVONOID FISETIN; LACTOCOCCUS-LACTIS; CORYNEBACTERIUM-GLUTAMICUM; ESCHERICHIA-COLI; ALPHA-SYNUCLEIN; SACCHAROMYCES-CEREVISIAE; ANTIOXIDANT CAPACITY; MICROBIAL-PRODUCTION; KNOCKOUT STRATEGIES;

D O I：

10.1007/s11101-017-9532-2

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using bacterial platforms. The project aimed at covering all stages of the discovery and pre-commercialization process, including berry collection, screening and characterization of their bioactive components, identification and functional characterization of the corresponding biosynthetic pathways, and construction of Gram-positive bacterial cell factories producing phenolic compounds. Further activities included optimization of polyphenol extraction methods from bacterial cultures, scale-up of production by fermentation up to pilot scale, as well as societal and economic analyses of the processes. This review article summarizes some of the key findings obtained throughout the duration of the project.

引用

页码：291 / 326

页数：36

共 180 条

[1] Enumeration of minimal stoichiometric precursor sets in metabolic networks [J].

Andrade, Ricardo ;

Wannagat, Martin ;

Klein, Cecilia C. ;

Acuna, Vicente ;

Marchetti-Spaccamela, Alberto ;

Milreu, Paulo V. ;

Stougie, Leen ;

Sagot, Marie-France .

ALGORITHMS FOR MOLECULAR BIOLOGY, 2016, 11

[2]

[Anonymous], NATURAL PRODUCTS

[3]

Aranaz I, 2016, IND BIORENEWABLES PR, P363

[4] Transgenic tobacco and Arabidopsis plants expressing the two multifunctional sorghum cytochrome P450 enzymes, CYP79A1 and CYP71E1, are cyanogenic and accumulate metabolites derived from intermediates in dhurrin biosynthesis [J].

Bak, S ;

Olsen, CE ;

Halkier, BA ;

Moller, BL .

PLANT PHYSIOLOGY, 2000, 123 (04) :1437-1448

[5] Bio-based production of chemicals, materials and fuels - Corynebacterium glutamicum as versatile cell factory [J].

Becker, Judith ;

Wittmann, Christoph .

CURRENT OPINION IN BIOTECHNOLOGY, 2012, 23 (04) :631-640

[6] Metabolic engineering of Saccharomyces cerevisiae for the synthesis of the wine-related antioxidant resveratrol [J].

Becker, JVW ;

Armstrong, GO ;

Van der Merwe, MJ ;

Lambrechts, MG ;

Vivier, MA ;

Pretorius, IS .

FEMS YEAST RESEARCH, 2003, 4 (01) :79-85

[7] Production of resveratrol in recombinant microorganisms [J].

Beekwilder, Jules ;

Wolswinkel, Rianne ;

Jonker, Harry ;

Hall, Robert ;

Ric de Vos, C. H. ;

Bovy, Arnaud .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2006, 72 (08) :5670-5672

[8]

Bergdahl B, 2015, FUNDAMENTAL BIOENGIN, P143

[9] Redirecting carbon flux into malonyl-CoA to improve resveratrol titers: Proof of concept for genetic interventions predicted by OptForce computational framework [J].

Bhan, Namita ;

Xu, Peng ;

Khalidi, Omar ;

Koffas, Mattheos A. G. .

CHEMICAL ENGINEERING SCIENCE, 2013, 103 :109-114

[10] Yeast as a model for studying Alzheimer's disease [J].

Bharadwaj, Prashant ;

Martins, Ralph ;

Macreadie, Ian .

FEMS YEAST RESEARCH, 2010, 10 (08) :961-969

← 1 2 3 4 5 6 7 8 9 10 →