The Epidemiology and Clinical Features of Balamuthia mandrillaris Disease in the United States, 1974-2016

被引:90
作者
Cope, Jennifer R. [1 ]
Landa, Janet [1 ,2 ]
Nethercut, Hannah [1 ,3 ]
Collier, Sarah A. [1 ]
Glaser, Carol [4 ]
Moser, Melanie [5 ]
Puttagunta, Raghuveer [1 ]
Yoder, Jonathan S. [1 ]
Ali, Ibne K. [1 ]
Roy, Sharon L. [6 ]
机构
[1] Ctr Dis Control & Prevent, Waterborne Dis Prevent Branch, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA
[2] James A Ferguson Emerging Infect Dis Fellowship P, Baltimore, MD USA
[3] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA
[4] Kaiser Permanente, San Francisco, CA USA
[5] Ctr Dis Control & Prevent, Off Financial Resources, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA USA
[6] Ctr Dis Control & Prevent, Parasit Dis Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA USA
关键词
Balamuthia mandrillaris; free-living ameba; granulomatous amebic encephalitis; FREE-LIVING AMEBAS; ORGAN-TRANSPLANTATION; ACANTHAMOEBA SPP; LEPTOMYXID-AMEBA; MENINGOENCEPHALITIS; ENCEPHALITIS; HUMANS; AGENT; TRANSMISSION; INFECTION;
D O I
10.1093/cid/ciy813
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background Balamuthia mandrillaris is a free-living ameba that causes rare, nearly always fatal disease in humans and animals worldwide. B. mandrillaris has been isolated from soil, dust, and water. Initial entry of Balamuthia into the body is likely via the skin or lungs. To date, only individual case reports and small case series have been published. Methods The Centers for Disease Control and Prevention (CDC) maintains a free-living ameba (FLA) registry and laboratory. To be entered into the registry, a Balamuthia case must be laboratory-confirmed. Several sources were used to complete entries in the registry, including case report forms, CDC laboratory results, published case reports, and media information. SAS (c) version 9.3 software was used to calculate descriptive statistics and frequencies. Results We identified 109 case reports of Balamuthia disease between 1974 and 2016. Most (99%) had encephalitis. The median age was 36 years (range 4 months to 91 years). Males accounted for 68% of the case patients. California had the highest number of case reports, followed by Texas and Arizona. Hispanics constituted 55% for those with documented ethnicity. Exposure to soil was commonly reported. Among those with a known outcome, 90% of patients died. Conclusions Balamuthia disease in the United States is characterized by a highly fatal encephalitis that affects patients of all ages. Hispanics were disproportionately affected. The southwest region of the United States reported the most cases. Clinician awareness of Balamuthia as a cause of encephalitis might lead to earlier diagnosis and initiation of treatment, resulting in better outcomes. We describe 109 case reports of Balamuthia disease in the United States between 1974 and 2016. Most were male with encephalitis, had a median age of 36 years, and were reported from southwestern states. Ninety percent of patients died.
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收藏
页码:1815 / 1822
页数:8
相关论文
共 44 条
[11]   Successful treatment of Balamuthia amoebic encephalitis:: Presentation of 2 cases [J].
Deetz, TR ;
Sawyer, MH ;
Billman, G ;
Schuster, FL ;
Visvesvara, GS .
CLINICAL INFECTIOUS DISEASES, 2003, 37 (10) :1304-1312
[12]   Balamuthia mandrillaris from soil samples [J].
Dunnebacke, TH ;
Schuster, FL ;
Yagi, S ;
Booton, GC .
MICROBIOLOGY-SGM, 2004, 150 :2837-2842
[13]   Isolation of Balamuthia amebas from the environment [J].
Dunnebacke, TH ;
Schuster, FL ;
Yagi, S ;
Booton, GC .
JOURNAL OF EUKARYOTIC MICROBIOLOGY, 2003, 50 :510-511
[14]   Transmission of Balamuthia mandrillaris by Organ Transplantation [J].
Farnon, Eileen C. ;
Kokko, Kenneth E. ;
Budge, Philip J. ;
Mbaeyi, Chukwuma ;
Lutterloh, Emily C. ;
Qvarnstrom, Yvonne ;
da Silva, Alexandre J. ;
Shieh, Wun-Ju ;
Roy, Sharon L. ;
Paddock, Christopher D. ;
Sriram, Rama ;
Zaki, Sherif R. ;
Visvesvara, Govinda S. ;
Kuehnert, Matthew J. .
CLINICAL INFECTIOUS DISEASES, 2016, 63 (07) :878-888
[15]   Multifocal Balamuthia mandrillaris infection in a dog in Australia [J].
Finnin, Peter J. ;
Visvesvara, Govinda S. ;
Campbell, Bronwyn E. ;
Fry, Darren R. ;
Gasser, Robin B. .
PARASITOLOGY RESEARCH, 2007, 100 (02) :423-426
[16]   Encephalitis Hospitalization Rates and Inpatient Mortality in the United States, 2000-2010 [J].
George, Benjamin P. ;
Schneider, Eric B. ;
Venkatesan, Arun .
PLOS ONE, 2014, 9 (09)
[17]  
Glaser C., 2008, Morbidity and Mortality Weekly Report, V57, P768
[18]   CULTURE ISOLATION OF ACANTHAMOEBA SPECIES AND LEPTOMYXID AMEBAS FROM PATIENTS WITH AMEBIC MENINGOENCEPHALITIS, INCLUDING 2 PATIENTS WITH AIDS [J].
GORDON, SM ;
STEINBERG, JP ;
DUPUIS, MH ;
KOZARSKY, PE ;
NICKERSON, JF ;
VISVESVARA, GS .
CLINICAL INFECTIOUS DISEASES, 1992, 15 (06) :1024-1030
[19]   Transmission of Balamuthia mandrillaris Through Solid Organ Transplantation: Utility of Organ Recipient Serology to Guide Clinical Management [J].
Gupte, A. A. ;
Hocevar, S. N. ;
Lea, A. S. ;
Kulkarni, R. D. ;
Schain, D. C. ;
Casey, M. J. ;
Zendejas-Ruiz, I. R. ;
Chung, W. K. ;
Mbaeyi, C. ;
Roy, S. L. ;
Visvesvara, G. S. ;
da Silva, A. J. ;
Tallaj, J. ;
Eckhoff, D. ;
Baddley, J. W. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2014, 14 (06) :1417-1424
[20]   Another case of canine amoebic meningoencephalitis-the challenges of reaching a rapid diagnosis [J].
Hodge, Priscilla J. ;
Kelers, Kylie ;
Gasser, Robin B. ;
Visvesvara, Govinda S. ;
Martig, Sandra ;
Long, Sam N. .
PARASITOLOGY RESEARCH, 2011, 108 (04) :1069-1073