Proteomic Identification of Pterostilbene-Mediated Anticancer Activities in HepG2 Cells

被引：14

作者：

Suganya, N. ^{[1
]}

Bhakkiyalakshmi, E. ^{[1
]}

Subin, T. S. ^{[2
]}

Krishnamurthi, K. ^{[2
]}

Devi, S. Saravana ^{[2
]}

Lau, K. ^{[3
]}

Sekar, T. V. ^{[3
]}

Paulmurugan, R. ^{[3
]}

Ramkumar, K. M. ^{[1
]}

机构：

[1] SRM Univ, SRM Res Inst, Kattankulathur, Tamilnadu, India

[2] Natl Environm Engn Res Inst, Div Environm Hlth, Nagpur 440020, Maharashtra, India

[3] Stanford Univ Sch Med, Dept Radiol, Stanford, CA 94305 USA

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2014年 / 27卷 / 07期

关键词：

POLYACRYLAMIDE-GEL-ELECTROPHORESIS; CONTROLLED TUMOR PROTEIN; PROSTATE-CANCER CELLS; G2/M PHASE ARREST; SIGNAL-TRANSDUCTION; COLORECTAL-CANCER; BREAST-CANCER; CYCLE ARREST; APOPTOSIS; HEPATOMA;

D O I：

10.1021/tx5001392

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the present study, we attempt to shed light on the underlying molecular mechanism of the anticancer activity of pterostilbene (PTS) in HepG2 cells through the proteomic approach. PTS was found to induce apoptosis by altering the expression of apoptotic genes and the G2/M phase of cell cycle arrest. Further, the 2-DE map showed the expression of 72 differentially regulated proteins in PTS-treated HepG2 cells, of which 8 spots with >2 fold up- or down-regulated level were identified by MALDI-TOF analysis, which has a regulatory role in apoptosis. These findings for the first time offer valuable insights into the mechanism of apoptotis by PTS in HepG2 cells.

引用

页码：1243 / 1252

页数：10

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