The diagnostic value of miR-21 combined with CT in patients with liver cancer

被引:8
作者
Feng, Y. S. [1 ]
Zhou, J. M. [2 ]
Sun, C. H. [3 ]
Zhu, J. [4 ]
Yang, J. [5 ]
Guo, L. [6 ]
机构
[1] Nanyang Med Coll, Affiliated Hosp 1, Dept CT Room, Nanyang 473058, Henan, Peoples R China
[2] Yantaishan Hosp, Dept Ultrasound Diag, Yantai 264000, Peoples R China
[3] Third Peoples Hosp Qingdao, Dept Hepatobiliary Surg, Qingdao 266041, Peoples R China
[4] Peoples Hosp Zhangqiu Area, Dept Resp Med, Jinan 250200, Peoples R China
[5] Peoples Hosp Zhangqiu Area, Dept Clin Lab, Jinan 250200, Peoples R China
[6] Shandong Univ, Cheeloo Coll Med, Jinan Cent Hosp, Dept Radiol, 105 Jiefang Rd, Jinan 250013, Shandong, Peoples R China
关键词
CT; miR-21; Liver cancer; Diagnosis; FOCAL NODULAR HYPERPLASIA; CONTRAST-ENHANCED ULTRASOUND; DIFFERENTIATION; EXPRESSION; MICRORNAS; PROGNOSIS; ACCURACY;
D O I
10.1007/s12094-020-02514-4
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose To explore the diagnostic value of miR-21 combined with computed tomography (CT) in patients with liver cancer. Methods A total of 112 patients in our hospital were confirmed liver cancer by examination, and were collected as cancer group. Another 100 patients with hepatic focal nodular hyperplasia in the same period were collected as control group. The diagnostic value of miR-21 and CT on liver cancer was observed. Results The level of miR-21 in cancer group was significantly higher than that in control group, the difference was statistically significant (p < 0.05). The alpha-fetoprotein (AFP) level was tested. It was found that the AFP level in cancer group was significantly higher than that in control group (p < 0.001). The correlation between AFP and miR-21 levels in liver cancer patients was detected. It turned out that AFP and miR-21 had correlation. According to receiver operating curve (ROC) calculation results, the best cut-off value for miR-21 diagnosis was 4.142. The sensitivity, specificity and accuracy of diagnosis of miR-21 alone were 64.29%, 87.00% and 75.00%, respectively. The sensitivity, specificity and accuracy of diagnosis of CT alone were 91.07%, 62.00% and 77.36%, respectively. There were 108 cases of true positive and 80 cases of true negative after combined diagnosis in the two groups. The sensitivity, specificity and accuracy of combined diagnosis were 96.43%, 80.00% and 88.68%, respectively. Comparing the value of single diagnosis and combined diagnosis, we found that the accuracy, sensitivity and specificity of combined diagnosis were significantly higher than that of single diagnosis (p < 0.05). Conclusion CT combined with miR-21 has great diagnostic value in liver cancer and may be a potential diagnostic indicator for liver cancer.
引用
收藏
页码:1238 / 1244
页数:7
相关论文
共 31 条
  • [1] Role of 18F-FDG PET-CT in initial staging of hepatocellular carcinoma and its impact on changing clinical decision
    Abdelhalim, Heba
    Houseni, Mohamed
    Elsakhawy, Mahmoud
    Abd Elbary, Naser
    Elabd, Osama
    [J]. EGYPTIAN LIVER JOURNAL, 2020, 10 (01)
  • [2] Anwar Sumadi Lukman, 2019, Asian Pac J Cancer Prev, V20, P1223
  • [3] Focal nodular hyperplasia and hepatocellular adenoma
    Bastati-Huber, N.
    Poetter-Lang, S.
    Ba-Ssalamah, A.
    [J]. RADIOLOGE, 2015, 55 (01): : 18 - 26
  • [4] Cai L, 2015, J INT TRANSL MED, V3, P28
  • [5] Application of imaging fusion combining contrast-enhanced ultrasound and magnetic resonance imaging in detection of hepatic cellular carcinomas undetectable by conventional ultrasound
    Dong, Yi
    Wang, Wen-Ping
    Mao, Feng
    Ji, Zheng-Biao
    Huang, Bei-Jian
    [J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2016, 31 (04) : 822 - 828
  • [6] Circulating miR-21 serves as a serum biomarker for hepatocellular carcinoma and correlated with distant metastasis
    Guo, Xin
    Lv, Xiaohui
    Lv, Xing
    Ma, Yueyun
    Chen, Lin
    Chen, Yong
    [J]. ONCOTARGET, 2017, 8 (27) : 44050 - 44058
  • [7] Serum microRNAs improving the diagnostic accuracy in lung cancer presenting with pulmonary nodules
    He, Yayi
    Ren, Shengxiang
    Wang, Yan
    Li, Xuefei
    Zhou, Caicun
    Hirsch, Fred R.
    [J]. JOURNAL OF THORACIC DISEASE, 2018, 10 (08) : 5080 - 5085
  • [8] Huang XW, 2018, J BUON, V23, P985
  • [9] MicroRNA gene expression deregulation in human breast cancer
    Iorio, MV
    Ferracin, M
    Liu, CG
    Veronese, A
    Spizzo, R
    Sabbioni, S
    Magri, E
    Pedriali, M
    Fabbri, M
    Campiglio, M
    Ménard, S
    Palazzo, JP
    Rosenberg, A
    Musiani, P
    Volinia, S
    Nenci, I
    Calin, GA
    Querzoli, P
    Negrini, M
    Croce, CM
    [J]. CANCER RESEARCH, 2005, 65 (16) : 7065 - 7070
  • [10] Jemal A, 2011, CA-CANCER J CLIN, V61, P134, DOI [10.3322/caac.20107, 10.3322/caac.20115, 10.3322/caac.21492]