The cross-selective titanium(III)-catalysed acyloin reaction

被引：35

作者：

Feurer, Markus ^{[1
]}

Frey, Georg ^{[1
]}

Hieu-Trinh Luu ^{[1
]}

Kratzert, Daniel ^{[2
]}

Streuff, Jan ^{[1
]}

机构：

[1] Univ Freiburg, Inst Organ Chem, D-79104 Freiburg, Germany

[2] Univ Freiburg, Inst Anorgan & Analyt Chem, D-79104 Freiburg, Germany

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 40期

关键词：

REDUCTIVE RADICAL CYCLIZATION; COUPLING REACTIONS; BASIS-SETS; TITANOCENE; KETONES; MECHANISM; ALDEHYDES; ENERGY;

D O I：

10.1039/c3cc46894a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A titanium(III)-catalysed intermolecular reductive coupling of ketones or imines with nitriles is described, which gives direct access to alpha-hydroxylated and alpha-aminated ketones. This coupling reaction is cross-selective and a catalytic version of the classical acyloin condensation. A reaction mechanism that is supported by first DFT calculations is discussed.

引用

页码：5370 / 5372

页数：3

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