Electrospun Scaffolds and Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Tissue Engineering Applications

被引：28

作者：

Suh, Taylor Cook ^{[1
]}

Amanah, Alaowei Y. ^{[1
]}

Gluck, Jessica M. ^{[1
]}

机构：

[1] NC State Univ, Wilson Coll Text, Text Engn Chem & Sci Dept, Raleigh, NC 27695 USA

来源：

BIOENGINEERING-BASEL | 2020年 / 7卷 / 03期

关键词：

tissue engineering; cardiac tissue engineering; engineered heart tissue; electrospinning; scaffolds; cardiomyocytes; induced pluripotent stem cells;

D O I：

10.3390/bioengineering7030105

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Tissue engineering (TE) combines cells, scaffolds, and growth factors to assemble functional tissues for repair or replacement of tissues and organs. Cardiac TE is focused on developing cardiac cells, tissues, and structures-most notably the heart. This review presents the requirements, challenges, and research surrounding electrospun scaffolds and induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs) towards applications to TE hearts. Electrospinning is an attractive fabrication method for cardiac TE scaffolds because it produces fibers that demonstrate the optimal potential for mimicking the complex structure of the cardiac extracellular matrix (ECM). iPSCs theoretically offer the capacity to generate limitless numbers of CMs for use in TE hearts, however these iPSC-CMs are electrophysiologically, morphologically, mechanically, and metabolically immature compared to adult CMs. This presents a functional limitation to their use in cardiac TE, and research aiming to address this limitation is presented in this review.

引用

页码：1 / 22

页数：21

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