A single dose of interleukin-31 (IL-31) causes continuous itch-associated scratching behaviour in mice

被引：64
作者：
Arai, Iwao [1 ,2 ]
Tsuji, Minoru [1 ]
Takeda, Hiroshi [1 ]
Akiyama, Nobutake [2 ]
Saito, Saburo [2 ]
机构：
[1] Int Univ Hlth & Welf, Div Pharmacol, Sch Pharm, Ohtawara, Tochigi 3248510, Japan
[2] Jikei Univ, Dept Mol Immunol, Inst DNA Med, Tokyo, Japan
来源：
EXPERIMENTAL DERMATOLOGY | 2013年 / 22卷 / 10期
关键词：
IL-31; itch; pruritogen; scratch; serotonin; NC/NGA MICE; ATOPIC-DERMATITIS; T-CELLS; SKIN; INVOLVEMENT; INDUCTION; STRAINS;
D O I：
10.1111/exd.12222
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
We investigated the effects of a single dose of mouse interleukin-31 (IL-31) on scratching behaviour in comparison with spontaneous skin-lesion- or serotonin (5-HT)- induced scratching behaviour in NC/Nga and BALB/c mice. Intradermal (i.d.) injection of IL-31 caused a gradual increase in long-lasting scratching (LLS, over 1.5s) about 3h after administration followed by a gradual decrease for over 24h after administration. I.d. injection of IL-31 significantly increased the total LLS counts/24h but not short-lasting scratching (SLS, 0.3-1.5s). In skin-lesioned NC/Nga mice, the LLS but not SLS counts were significantly higher than those in non-skin-lesioned NC/Nga mice. We also investigated 5-HT-induced scratching in BALB/c mice, SLS but not LLS increased immediately after the injection and then decreased to baseline after at 20min. These results suggest that IL-31 may participate in the sensation of itching and promote scratching behaviour in skin-lesioned NC/Nga mice, an animal model of atopic dermatitis (AD).
引用
收藏
页码：669 / 671
页数：3
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