Reductive Cleavage of Aromatic and Heteroaromatic Ester Functions via Copper-Catalyzed Proto-Decarbomethoxylation

被引：12

作者：

Fichez, Jeanne ^{[1
]}

Prestat, Guillaume ^{[1
]}

Busca, Patricia ^{[1
]}

机构：

[1] Univ Paris 05, Lab Chim & Biochim Pharmacol & Toxicol, CNRS, UMR 8601, F-75006 Paris, France

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 09期

关键词：

C-H ARYLATION; (HETERO)AROMATIC CARBOXYLIC-ACIDS; BIARYL SYNTHESIS; BENZOIC-ACIDS; DECARBONYLATIVE BORYLATION; GROUP INTERCONVERSION; 2-NITROBENZOIC ACIDS; CUPROUS CARBOXYLATES; NICKEL CATALYSIS; DIRECTING GROUPS;

D O I：

10.1021/acs.orglett.8b00930

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented catalytic reductive cleavage of aromatic and heteroaromatic methyl ester functions was successfully achieved with a cheap, nontoxic, and air-stable Cu(OAc)(2) catalyst. This reaction is fast, features good functional group tolerance, does not require inert atmosphere or anhydrous solvent, and can be scaled up to 1 g. Moreover, carboxylic acids and t-butyl esters also reacted smoothly under these conditions.

引用

页码：2724 / 2727

页数：4

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