Commentary - The function of AID in somatic mutation and class switch recombination: Upstream or downstream of DNA breaks

被引：23
作者：
Chua, KF
Alt, FW
Manis, JP
机构：
[1] Harvard Univ, Sch Med, Childrens Hosp, Ctr Blood Res, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
来源：
JOURNAL OF EXPERIMENTAL MEDICINE | 2002年 / 195卷 / 09期
关键词：
D O I：
10.1084/jem.20020380
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
引用
收藏
页码：F37 / F41
页数：5
相关论文
共 36 条
[1]   Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion [J].
Arakawa, H ;
Hauschild, J ;
Buerstedde, JM .
SCIENCE, 2002, 295 (5558) :1301-1306
[2]   Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) or recombination-activating gene (RAG)1 activity [J].
Bemark, M ;
Sale, JE ;
Kim, HJ ;
Berek, C ;
Cosgrove, RA ;
Neuberger, MS .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (10) :1509-1514
[3]   Deletion of the IgH intronic enhancer and associated matrix-attachment regions decreases, but does not abolish, class switching at the μ locus [J].
Bottaro, A ;
Young, F ;
Chen, JZ ;
Serwe, M ;
Sablitzky, F ;
Alt, FW .
INTERNATIONAL IMMUNOLOGY, 1998, 10 (06) :799-806
[4]   ORIGIN OF ANTIBODY VARIATION [J].
BRENNER, S ;
MILSTEIN, C .
NATURE, 1966, 211 (5046) :242-&
[5]   DNA double-strand breaks: Prior to but not sufficient in targeting hypermutation [J].
Bross, L ;
Muramatsu, M ;
Kinoshita, K ;
Honjo, T ;
Jacobs, H .
JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (09) :1187-1192
[6]   DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation [J].
Bross, L ;
Fukita, Y ;
McBlane, F ;
Démollière, C ;
Rajewsky, K ;
Jacobs, H .
IMMUNITY, 2000, 13 (05) :589-597
[7]   Ku80 is required for immunoglobulin isotype switching [J].
Casellas, R ;
Nussenzweig, A ;
Wuerffel, R ;
Pelanda, R ;
Reichlin, A ;
Suh, H ;
Qin, XF ;
Besmer, E ;
Kenter, A ;
Rajewsky, K ;
Nussenzweig, MC .
EMBO JOURNAL, 1998, 17 (08) :2404-2411
[8]   MUTATIONS, DUPLICATION, AND DELETION OF RECOMBINED SWITCH REGIONS SUGGEST A ROLE FOR DNA-REPLICATION IN THE IMMUNOGLOBULIN HEAVY-CHAIN SWITCH [J].
DUNNICK, W ;
WILSON, M ;
STAVNEZER, J .
MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (05) :1850-1856
[9]   DNA-SEQUENCES AT IMMUNOGLOBULIN SWITCH REGION RECOMBINATION SITES [J].
DUNNICK, W ;
HERTZ, GZ ;
SCAPPINO, L ;
GRITZMACHER, C .
NUCLEIC ACIDS RESEARCH, 1993, 21 (03) :365-372
[10]   COPY CHOICE MECHANISM OF IMMUNOGLOBULIN HEAVY-CHAIN SWITCH RECOMBINATION [J].
DUNNICK, W ;
STAVNEZER, J .
MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (01) :397-400
1234