A lucid review of Helicobacter pylori-induced DNA damage in gastric cancer

被引：23

作者：

Fu, Li ^{[1
]}

Xie, Chuan ^{[1
]}

机构：

[1] Nanchang Univ, Affiliated Hosp 1, Dept Gastroenterol, 17 Yong Waizheng St, Nanchang 330006, Jiangxi, Peoples R China

来源：

HELICOBACTER | 2019年 / 24卷 / 05期

基金：

中国国家自然科学基金;

关键词：

DNA damage; Helicobacter pylori; NF-kappa B; PLK; DOUBLE-STRAND BREAKS; NF-KAPPA-B; EPITHELIAL-CELL SURVIVAL; CAGA PROTEIN; GENETIC INSTABILITY; OXIDATIVE STRESS; REACTIVE OXYGEN; INFECTION; PHOSPHORYLATION; INFLAMMATION;

D O I：

10.1111/hel.12631

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Helicobacter pylori (H pylori) is the main risk factor for gastric cancer (GC). In recent years, many studies have addressed the effects of H pylori itself and of H pylori-induced chronic inflammation on DNA damage. Unrepaired or inappropriately repaired DNA damage is one possible carcinogenic mechanism. We may conclude that H pylori-induced DNA damage is one of the carcinogenic mechanisms of GC. In this review, we summarize the interactions between H pylori and DNA damage and the effects of H pylori-induced DNA damage on GC. Then, focusing on oxidative stress, we introduce the application of antioxidants in GC. At the end of this review, we discuss the outlook for further research on H pylori-induced DNA damage.

引用

页数：9

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